Association of Timely Comprehensive Genomic Profiling with Precision Oncology Treatment Use and Patient Outcomes in Advanced Non-Small-Cell Lung Cancer

Association of Timely Comprehensive Genomic Profiling with Precision Oncology Treatment Use and Patient Outcomes in Advanced Non-Small-Cell Lung Cancer

Medicine, Respiratory System, Oncology,
non-small-cell lung cancer   genomic profiling   precision oncology   immune checkpoint inhibitors   survival rate   treatment selection  

Study on the Association Between the Timeliness of Comprehensive Genomic Profiling in Precision Oncology and Treatment Choices and Outcomes for Patients with Advanced Non-Small Cell Lung Cancer Introduction Advanced non-small-cell lung cancer (ANSCLC) is a highly lethal malignancy, and treatment choices directly affect the overall survival rate of ...

GRIN2A mutation is a novel indicator of stratifying beneficiaries of immune checkpoint inhibitors in multiple cancers

Medicine, Rheumatology and Immunology, Basic Medical Sciences, Oncology, Life Sciences, Biochemistry, Immunology,
GRIN2A mutation   cancer immunotherapy   immune checkpoint inhibitors   tumor mutational burden   tumor-infiltrating immune cells  

GRIN2A Mutations as a Novel Indicator for Stratifying Beneficiaries of Immune Checkpoint Inhibitors in Various Cancers Background Immune checkpoint inhibitors (ICIs) therapy, which modulates the cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and programmed cell death (ligand) 1 (PD-(L)1) pathways, has made revolutionary progress in treating v...