Mitochondrial Transfer and Immune Evasion Mechanisms in the Tumor Microenvironment Academic Background Tumor cells evade immune system attacks, particularly by T cells, through various mechanisms in the Tumor Microenvironment (TME). Although Immune Checkpoint Inhibitors (ICIs) have achieved significant progress in the treatment of various cancers, ...
Enhancing Immunotherapy Potential Through PD-L1 Upregulation—Combination of Anti-PD-L1 and mTOR Inhibitors Background Introduction In recent years, immune checkpoint inhibitors (ICIs) have made significant progress in cancer treatment, particularly in the treatment of urothelial cancer (UC). PD-1/PD-L1 inhibitors restore T cell anti-tumor activity ...
Academic Background and Problem Statement In recent years, immune checkpoint inhibitors (ICIs) have made significant progress in cancer treatment, particularly anti-PD-1 and anti-PD-L1 antibodies, which have become the standard of care for first-line treatment in various cancers. However, despite the notable clinical activity of these therapies in ...
Background and Research Motivation Obesity has been identified as an important risk factor for various malignancies. It not only promotes the growth and spread of tumor cells but also leads to generally poorer prognosis in patients. However, recent research has found that obese patients receiving immune checkpoint inhibitors (ICI) therapy, especial...
Study on the Association Between the Timeliness of Comprehensive Genomic Profiling in Precision Oncology and Treatment Choices and Outcomes for Patients with Advanced Non-Small Cell Lung Cancer Introduction Advanced non-small-cell lung cancer (ANSCLC) is a highly lethal malignancy, and treatment choices directly affect the overall survival rate of ...
GRIN2A Mutations as a Novel Indicator for Stratifying Beneficiaries of Immune Checkpoint Inhibitors in Various Cancers Background Immune checkpoint inhibitors (ICIs) therapy, which modulates the cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and programmed cell death (ligand) 1 (PD-(L)1) pathways, has made revolutionary progress in treating v...