A Missense Variant in AIFM1 Caused Mitochondrial Dysfunction and Intolerance to Riboflavin Deficiency

Medicine, Basic Medical Sciences, Neurology, Life Sciences, Cell Biology, Biochemistry, Genetics,
AIFM1   mitochondria   riboflavin   apoptosis   ataxia   neuropathy  

Missense Mutation in AIFM1 Gene Leads to Mitochondrial Dysfunction and Riboflavin Deficiency Intolerance Research Background Mitochondria are double-membrane organelles found in eukaryotic cells with nuclei, primarily producing adenosine triphosphate (ATP) through oxidative phosphorylation to provide cellular energy. Mitochondria have their own gen...

Gene Expression Alterations in the Spinal Cord of SIV-Infected Macaques on Antiretroviral Therapy

Medicine, Infectious Diseases, Neurology, Life Sciences, Cell Biology, Immunology,
SIV   HIV   spinal cord   antiretroviral therapy   gene expression   neuropathy  

NARP Laboratory Research Reveals the Impact of SIV Infection on Spinal Cord Gene Expression Background Despite the implementation of antiretroviral therapy (ART), HIV-associated peripheral neuropathy (HIV-DSP) remains one of the most common neurological manifestations of HIV infection. Clinical symptoms of HIV-DSP include weakness, numbness, burnin...