Targeting ADAR1 with a Small Molecule for the Treatment of Prostate Cancer

Academic Background Prostate cancer (PCA) is one of the most common malignancies in men, particularly in Western countries, where it is the second leading cause of cancer-related deaths among males. Although androgen signaling therapy is effective in the initial treatment of prostate cancer, most patients eventually relapse, and there is currently ...

Potent Function of CD70-Targeted iPSC-Derived CAR-NK Cells Against Tumors and Alloreactive T Cells

Potent Function of CD70-Targeted iPSC-Derived CAR-NK Cells Against Tumors and Alloreactive T Cells

Targeting CD70 with iPSC-Derived CAR-NK Cell Therapy Background and Objectives of the Study Over the past decade, cellular therapy for cancer has revolutionized traditional treatment concepts by introducing the idea of a “living drug.” In particular, chimeric antigen receptor T cell (CAR-T) therapy has drastically improved the efficacy of immunothe...