The Role of Dysregulated miRNA-140 and miRNA-122 in Alzheimer's Disease

Medicine, Geriatrics, Neurology, Life Sciences, Biochemistry, Immunology,
Alzheimer's Disease   miRNA-140   miRNA-122   ADAM10   Cognitive Impairment   Neuroinflammation  

Analysis and Potential Applications of miRNAs Related to Alzheimer’s Disease Background and Research Motivation Alzheimer’s Disease (AD) is a progressively worsening neurodegenerative disorder and the most common form of dementia among the elderly. The pathological features of AD in the brain primarily include senile plaques formed by the accumulat...

Astrocytic Stress Response Induced by Exposure to Astrocyte-Binding Antibodies in Pediatric Acute Transverse Myelitis Cases

Medicine, Pediatrics, Rheumatology and Immunology, Neurology, Hematology, Life Sciences, Immunology,
Pediatric   Acute Transverse Myelitis   Astrocytes   Antibodies   Neuroinflammation  

B-cell Response in Pediatric Acute Transverse Myelitis Acute transverse myelitis (ATM) is an autoimmune-mediated inflammatory disease of the spinal cord with an incidence of 1.7-2 cases per million children per year. ATM typically presents with limb weakness, sensory loss, and bladder/bowel dysfunction, with symptoms rapidly developing over hours t...

Microglial PDCD4 Deficiency Mitigates Neuroinflammation-Associated Depression via Facilitating Daxx Mediated PPARγ/IL-10 Signaling

Medicine, Infectious Diseases, Psychiatry, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology,
Microglia   PDCD4   Neuroinflammation   Depression   PPARγ   IL-10  

Deletion of Microglia PDCD4 Alleviates Neuroinflammation-Associated Depression by Promoting DAXX-Mediated PPARγ/IL-10 Signaling Background In recent years, neuroinflammatory processes have been demonstrated to be associated with various psychiatric disorders, including schizophrenia, depression, and anxiety. A common feature of these diseases is th...