The Influence of Glioblastoma Differentiation on Blood-Brain Barrier Permeability

Medicine, Neurology, Oncology,
Glioblastoma   Blood-Brain Barrier   Permeability   IL-6   STAT3   Tumor Differentiation   Drug Delivery  

The Impact of Glioblastoma Differentiation on Blood-Brain Barrier Permeability Background Introduction Glioblastoma Multiforme (GBM) is a highly aggressive brain tumor, and its treatment is extremely challenging due to its complex biological characteristics and the presence of the Blood-Brain Barrier (BBB). The BBB is a complex structure composed o...

The Antitumor Activity of TGFβ-Specific T Cells is Dependent on IL-6 Signaling

Medicine, Rheumatology and Immunology, Oncology, Life Sciences, Cell Biology, Immunology,
TGFβ   IL-6   immunosuppression   tumor microenvironment   vaccines  

Review of the Study on the Relationship Between IL-6 Signaling and the Anti-Tumor Activity of TGFβ-Specific T Cells Background and Significance of the Study Interleukin-6 (IL-6) is a pleiotropic cytokine that plays a critical role in inflammation and hematopoiesis. However, its role in the immune system is context-dependent. While it has pro-inflam...

Increased IL-6 Levels and the Upregulation of Iron Regulatory Biomarkers Contribute to the Progression of Japanese Encephalitis Virus Infection's Pathogenesis

Medicine, Infectious Diseases, Neurology, Hematology, Life Sciences, Cell Biology, Immunology,
Japanese encephalitis virus infection   hepcidin   transferrin   transferrin receptors   IL-6  

Elevated IL-6 Levels and Upregulation of Iron-Regulatory Biomarkers Promote Japanese Encephalitis Virus Infection In this research paper, the authors explore changes in inflammatory response and iron-regulatory biomarkers during Japanese Encephalitis Virus (JEV) infection. A comprehensive analysis of iron-regulatory biomarkers and inflammatory resp...

Doxycycline-loaded calcium phosphate nanoparticles with a pectin coat can ameliorate lipopolysaccharide-induced neuroinflammation via enhancing AMPK

Chemistry, Nanoscience, Medicine, Neurology, Life Sciences, Biochemistry, Immunology,
neuroinflammation   AMPK   TLR-4   NRF2   IL-6   doxycycline  

Protective Effect of Doxycycline-Loaded Calcium Phosphate Nanoparticles on LPS-Induced Neuroinflammation in Mice In the field of neuroscience research, neuroinflammation is an important pathological feature of many neurological diseases. Neuroinflammation is a complex response of the central nervous system (CNS) to various damaging triggers (such a...

Tumor-Associated NK Cells Drive MDSC-Mediated Tumor Immune Tolerance Through the IL-6/STAT3 Axis

Medicine, Oncology, Life Sciences, Immunology,
NK cells   MDSC   tumor immune escape   IL-6   STAT3   antigen presentation   immune checkpoint inhibition  

Tumor-Associated NK Cells Drive MDSC-Mediated Tumor Immune Tolerance via the IL-6/STAT3 Axis — Research by Neo et al. In recent years, researchers have delved deeply into the mechanisms of tumor immune escape to improve the success rate of cancer immunotherapy. The accumulation of CD8 T cells in the tumor microenvironment is a critical determinant ...