Association Between Body Composition Patterns, Cardiovascular Disease, and Risk of Neurodegenerative Disease in the UK Biobank

Study on the Association# Study on the Association Between Body Composition Patterns, Cardiovascular Diseases Between, Body and Neurodegenerative Composition Disease Risks Background Neurodegenerative Patterns diseases, including Alzheimer’s Disease (AD) and Parkinson’s Disease, (PD), currently affect over Cardiovascular Diseases, and Neuro60degene...

Validity of European-Centric Cardiometabolic Polygenic Scores in Multi-Ancestry Populations

Effectiveness of European-derived Cardiometabolic Polygenic Scores in Multi-ancestral Populations In recent years, Polygenic Scores (PGS) have received widespread attention as a tool for assessing individual genetic risk. However, most existing PGS are based on Genome-Wide Association Studies (GWAS) data from white European populations. This has le...

Investigating the impact of poverty on mental illness in the UK Biobank using Mendelian randomization

Study on the Impact of Poverty on Mental Illness: A Mendelian Randomization Analysis Based on the UK Biobank This article aims to explore the causal relationship between poverty and mental illness. Although many studies have shown an association between low socioeconomic status and mental illnesses, most studies have failed to determine whether pov...

Identifying behaviour-related and physiological risk factors for suicide attempts in the UK Biobank

Research Background: Suicide is a global public health challenge, but there is still significant uncertainty regarding the relationship between behavioral and physiological factors and suicide attempts (SA). Previous studies often focus on limited hypothesized factors such as mental illnesses (e.g., depression), personality and psychological traits...

Principled distillation of UK Biobank phenotype data reveals underlying structure in human variation

In this report, we present a detailed evaluation of a research paper published in the journal Nature Human Behaviour, titled “Principled Refinement of UK Biobank Phenotypic Data Reveals the Latent Structure of Human Variation.” The study, conducted by Caitlin E. Carey, Rebecca Shafee, Robbee Wedow, among others, was published online on XX XX, XXXX....