A Review on the Mechanisms of Spatial and Temporal Integration and Competition in the Hippocampus Research Background and Significance In the human and animal brain, space and time comprise the primary dimensions of episodic memory, playing a crucial role in encoding information such as event sequences, locations, and durations. It has long been fo...

Study on Myosin Va-dependent NMDA Receptor Transport Mechanism in Hippocampal Neurons In hippocampal neurons, NMDA receptors (N-Methyl-D-Aspartate Receptor, abbreviated as NMDAR) are a subtype of glutamate receptors, crucial for regulating postsynaptic responses and various brain functions. The number of NMDARs in the postsynaptic region can change...

Association Between Epigenetic Age Acceleration Estimates and Cognitive Trajectories in the Women’s Health Initiative Memory Study Background Maintaining cognitive function is crucial for independent living among older adults. With the growth of the aging population, cognitive decline has become a significant public health challenge. Many studies h...

Epilepsy is one of the most common neurological disorders, with temporal lobe epilepsy (TLE) being the most prevalent form of drug-resistant epilepsy in adults. Numerous studies have indicated that TLE involves not only pathological changes in the medial temporal lobe but also affects widespread brain structures and functions. In this scientific re...

Differentiating Visual and Semantic Information in Human Perception and Memory Using Deep Neural Networks Introduction In cognitive science, the study of how humans recognize individuals and objects during perception and memory processes has long been of interest. Successful recognition of people and objects relies on matching representations gener...

Report: Revealing White Matter Changes Associated with Tau in Early Alzheimer’s Disease through Fixel-based Analysis Research Background Alzheimer’s Disease (AD) is generally thought to primarily affect the grey matter (GM), but more and more evidence shows that the white matter (WM) also experiences abnormalities. Current research largely relies o...

Circuit-Based Neuromodulation Enhances Delayed Recall Ability in Patients with Mild Cognitive Impairment Introduction As the aging population increases, amnestic mild cognitive impairment (AMCl) is receiving more attention. AMCl is seen as an important transitional stage from normal cognitive function to dementia and is a hotspot for studying cogni...