Electron Transport Chain Inhibition Increases Cellular Dependence on Purine Transport and Salvage

Medicine, Basic Medical Sciences, Oncology, Life Sciences, Cell Biology, Biochemistry,
electron transport chain   purine metabolism   cell growth   metabolic reprogramming   non-small cell lung cancer  

Inhibition of the electron transport chain increases cell dependence on purine transport and salvage Research Background The electron transport chain (ETC) is a key mechanism in mitochondria responsible for energy generation, playing an important role in maintaining cellular homeostasis and growth. However, it remains unclear how cells adjust their...

Immunotherapy Efficacy Prediction for Non-Small Cell Lung Cancer Using Multi-View Adaptive Weighted Graph Convolutional Networks

Information Science, Computer Science, Artificial Intelligence, Medicine, Medical Imaging, Oncology, Life Sciences, Immunology,
immunotherapy   non-small cell lung cancer   graph convolutional networks   multi-view   radiomics  

Research Report on Immunotherapy Efficacy Prediction for Non-Small Cell Lung Cancer: A Study of Multi-View Adaptive Weighted Graph Convolutional Networks Background Introduction Lung cancer is a highly prevalent and poorly prognostic malignant tumor with a persistently high mortality rate. Among all lung cancer patients, Non-Small Cell Lung Cancer ...

Representation of Genomic Intratumor Heterogeneity in Multi-Region Non-Small Cell Lung Cancer Patient-Derived Xenograft Models

Medicine, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
non-small cell lung cancer   xenograft models   tumor heterogeneity   genomic evolution   multi-region sampling  

Manifestations of Genomic-Level Intratumoral Tumor Heterogeneity in Multi-Region Patient-Derived Xenograft Models of Non-Small Cell Lung Cancer Academic Background and Research Motivation Patient-Derived Xenograft (PDX) models are widely used in cancer research. PDX models are established by transplanting human tumors into immunodeficient mice. The...