Identification of Clonal Hematopoiesis Driver Mutations Through In Silico Saturation Mutagenesis

Introduction In the process of healthy hematopoiesis, a group of hematopoietic stem cells (HSC) contribute to all blood-related lineages. However, as we age, this process often leads to clonal hematopoiesis (CH), meaning the expansion of clones originating from a particular HSC, which then occupies a significant portion of blood cells and platelets...

Identifying behaviour-related and physiological risk factors for suicide attempts in the UK Biobank

Research Background: Suicide is a global public health challenge, but there is still significant uncertainty regarding the relationship between behavioral and physiological factors and suicide attempts (SA). Previous studies often focus on limited hypothesized factors such as mental illnesses (e.g., depression), personality and psychological traits...

Crowd-sourced Benchmarking of Single-sample Tumor Subclonal Reconstruction

Single-Sample Tumor Subclonal Reconstruction Algorithm Based on Crowd-Sourced Resources Background The evolution of cancer and the genetic heterogeneity of tumors are critical fields in modern oncology research. Tumors evolve from normal cells through progressive acquisition of somatic mutations. These mutations occur probabilistically, influenced ...

brainlife.io: a decentralized and open-source cloud platform to support neuroscience research

Academic report: brainlife.io: A decentralized and open-source cloud platform supporting neuroscience research Background and Motivation Neuroscience research is rapidly developing, and the advancement of data standardization, management, and processing tools has made research more rigorous and transparent. However, this also brings about complex d...

Prediction error processing and sharpening of expected information

Prediction error processing and sharpening of expected information

Scientific Report Background Introduction Perception and neuronal processing of sensory information are largely influenced by prior expectations. Perception is not merely passive reception, but an active inferential process by combining existing sensory information with prior information based on past experience and current context. The combination...

A GRU-CNN Model for Auditory Attention Detection using Microstate and Recurrence Quantification Analysis

Overview and Report: Application of GRU-CNN Model Based on Microstate and Recurrence Quantification Analysis in Auditory Attention Detection Background and Research Motivation Attention, as a cognitive ability, plays a crucial role in the perception process, helping humans to focus on specific objects while ignoring other distractions in a complex ...

Revealing the Mechanisms of Semantic Satiation with Deep Learning Models

Revealing the Mechanisms of Semantic Satiation with Deep Learning Models

Deep Learning Model Reveals Mechanisms of Semantic Satiation Semantic satiation, the phenomenon where a word or phrase loses its meaning after being repeated many times, is a well-known psychological phenomenon. However, the micro-neural computational principles underlying this mechanism remain unknown. This paper uses a continuous coupled neural n...

Representation of Internal Speech by Single Neurons in Human Supramarginal Gyrus

“Internal Speech Representation by Single Neurons in Human Supramarginal Gyrus” Scientific Report Background In recent years, Brain-Machine Interfaces (BMIs) technology has made significant advancements in the field of speech decoding. BMIs enable those who have lost the ability to speak due to disease or injury to communicate again by converting b...

Cortex-wide Topography of 1/f-exponent in Parkinson’s Disease

Cortex-wide Topography of 1/f-exponent in Parkinson’s Disease

Topographical Map of the 1/f Index in the Whole Brain for Parkinson’s Disease Authors: Pascal Helson, Daniel Lundqvist, Per Svenningsson, Mikkel C. Vinding, Arvind Kumar Research Background Parkinson’s Disease (PD) is a progressive and debilitating brain disorder primarily characterized by motor dysfunction but also affecting perceptual and cogniti...

k-emophone: a mobile and wearable dataset with in-situ emotion, stress, and attention labels

Scientific Data Report | K-emophone: A Mobile and Wearable Dataset with On-site Emotion, Stress, and Attention Labels Background With the proliferation of low-cost mobile and wearable sensors, numerous studies have leveraged these devices to track and analyze human mental health, productivity, and behavioral patterns. However, despite the developme...