T-cell receptors (TCRs) play a crucial role in the adaptive immune system by recognizing pathogens through binding to specific antigen epitopes. Understanding the interactions between TCRs and epitopes is essential for uncovering the biological mechanisms of immune responses and developing T cell-mediated immunotherapies. However, although the impo...
Academic Background The COVID-19 pandemic has had a significant impact on global public health systems. Although the pandemic has somewhat subsided, its complex immunopathological mechanisms, long-term sequelae (such as “long COVID”), and the potential for similar threats in the future continue to drive in-depth research. Severe COVID-19 cases are ...
How COVID-19 Vaccines Affect Immune Responses During Breakthrough Infections Background Introduction As the COVID-19 pandemic continues, an increasing number of infections are “breakthrough infections,” occurring in individuals who have been vaccinated or previously infected with SARS-CoV-2. Although vaccination has significantly reduced the risk o...
Exploration of a Novel Pulmonary Anti-SARS-CoV-2 Therapy Based on MIL-100(Fe) In recent years, global public health has faced numerous severe challenges, particularly since 2019 with the outbreak of the SARS-CoV-2 coronavirus pandemic. The high transmission rate and persistence of the virus have exposed bottlenecks in current prevention and treatme...
Lifetime Risk of Surgery in England: A Nationwide Observational Cohort Study Academic Background Surgery represents a significant portion of the UK National Health Service (NHS) activity, with approximately 4.4 million people undergoing surgical procedures in England each year. Although an increasing number of surgeries are performed as day-case pr...
Comparative Analysis of Recombinant Quadrivalent Influenza Vaccine and Standard Egg-Based Quadrivalent Influenza Vaccine in Nursing Home Residents: A Cluster Randomized Trial Academic Background Influenza is among the primary respiratory pathogens causing morbidity and mortality among the elderly worldwide, particularly in nursing home residents wh...
Report on the Increasing Rates of Distant-Stage Breast Cancer in U.S. Women Academic Background Breast cancer is the second leading cause of cancer death among U.S. women, following lung cancer. Although screening mammography has been shown to significantly reduce breast cancer mortality, screening rates in the U.S. remain low, particularly among w...
The Relationship Between Mask Effectiveness and Population Coverage Rates Background and Research Motivation During the COVID-19 pandemic, non-pharmaceutical interventions (NPIs) such as social distancing, mask-wearing, and test-trace-isolate strategies were widely applied to control the spread of the virus. Despite a large body of empirical resear...
Research on Network Construction and Application of Novel Drug Repositioning Strategies Background During the COVID-19 pandemic, researchers and pharmaceutical companies have been dedicated to developing treatments and vaccines. Drug repositioning, due to its shortcut, is considered a rapid and effective response strategy. Drug repositioning attemp...
Using Medical Records to Predict Common Disease Incidence and Support Rapid Response to Emerging Health Threats Research Background and Motivation The COVID-19 pandemic exposed systemic issues and a lack of data-driven guidance globally, significantly affecting the identification of high-risk populations and pandemic preparedness. Assessing individ...