The Lifetime Risk of Surgery in England: A Nationwide Observational Cohort Study

Medicine, Obstetrics and Gynecology, Anesthesiology,
lifetime risk   surgery   COVID-19   epidemiology   public health   resource planning   cohort study  

Lifetime Risk of Surgery in England: A Nationwide Observational Cohort Study Academic Background Surgery represents a significant portion of the UK National Health Service (NHS) activity, with approximately 4.4 million people undergoing surgical procedures in England each year. Although an increasing number of surgeries are performed as day-case pr...

Recombinant vs Egg-Based Quadrivalent Influenza Vaccination for Nursing Home Residents: A Cluster Randomized Trial

Medicine, Infectious Diseases, Geriatrics,
influenza vaccine   nursing home   randomized trial   recombinant vaccine   egg-based vaccine   hospitalization rates   COVID-19  

Comparative Analysis of Recombinant Quadrivalent Influenza Vaccine and Standard Egg-Based Quadrivalent Influenza Vaccine in Nursing Home Residents: A Cluster Randomized Trial Academic Background Influenza is among the primary respiratory pathogens causing morbidity and mortality among the elderly worldwide, particularly in nursing home residents wh...

Increasing Rates of Distant-Stage Breast Cancer at Presentation in U.S. Women

Medicine, Oncology,
breast cancer   distant-stage cancer   incidence rates   U.S. women   COVID-19   screening   racial disparities  

Report on the Increasing Rates of Distant-Stage Breast Cancer in U.S. Women Academic Background Breast cancer is the second leading cause of cancer death among U.S. women, following lung cancer. Although screening mammography has been shown to significantly reduce breast cancer mortality, screening rates in the U.S. remain low, particularly among w...

Simulation Study Suggests Masks Can Become More Effective When Fewer People Wear Them

Mathematics, Medicine, Infectious Diseases, Environmental and Public Health,
simulation study   masks   non-pharmaceutical interventions   COVID-19   transmission control  

The Relationship Between Mask Effectiveness and Population Coverage Rates Background and Research Motivation During the COVID-19 pandemic, non-pharmaceutical interventions (NPIs) such as social distancing, mask-wearing, and test-trace-isolate strategies were widely applied to control the spread of the virus. Despite a large body of empirical resear...

Development of Complemented Comprehensive Networks for Rapid Screening of Repurposable Drugs Applicable to New Emerging Disease Outbreaks

Chemistry, Medicinal Chemistry, Information Science, Computer Science, Artificial Intelligence, Medicine, Medical Laboratory Science, Pharmacy, Life Sciences, Immunology, Microbiology,
drug repurposing   network medicine   graph-based semi-supervised learning   COVID-19  

Research on Network Construction and Application of Novel Drug Repositioning Strategies Background During the COVID-19 pandemic, researchers and pharmaceutical companies have been dedicated to developing treatments and vaccines. Drug repositioning, due to its shortcut, is considered a rapid and effective response strategy. Drug repositioning attemp...

Medical History Predicts Phenome-Wide Disease Onset and Enables the Rapid Response to Emerging Health Threats

Information Science, Artificial Intelligence, Medicine, Environmental and Public Health,
medical history   disease prediction   rapid response   COVID-19   neural network   risk stratification  

Using Medical Records to Predict Common Disease Incidence and Support Rapid Response to Emerging Health Threats Research Background and Motivation The COVID-19 pandemic exposed systemic issues and a lack of data-driven guidance globally, significantly affecting the identification of high-risk populations and pandemic preparedness. Assessing individ...