Pro-inflammatory and Hyperinsulinaemic Dietary Patterns are Associated with Specific Gut Microbiome Profiles: A TwinsUK Cohort Study

Medicine, Endocrinology, Gastroenterology, Life Sciences, Biochemistry, Microbiology,
pro-inflammatory diet   hyperinsulinaemic diet   gut microbiome   insulin resistance   chronic inflammation  

In recent years, the role of the gut microbiome in human health and disease has garnered significant attention. Research indicates that gut microbial dysbiosis is closely associated with various chronic diseases, such as obesity, inflammatory bowel disease, cancer, and neurodegenerative disorders. Diet, as a critical factor influencing the gut micr...

Ketones in Cellular Physiology: Metabolic, Signaling, and Therapeutic Advances

Medicine, Geriatrics, Endocrinology, Neurology,
ketones   brain-derived neurotrophic factor   cognitive function   insulin resistance   Alzheimer's disease  

Effects of Exogenous β-Hydroxybutyrate on BDNF Signaling, Cognition, and Amyloid Precursor Protein Processing in Humans with Type 2 Diabetes and Insulin-Resistant Rodents Academic Background Patients with type 2 diabetes (T2D) have a significantly increased risk of developing neurodegenerative diseases, such as Alzheimer’s disease (AD), later in li...

Endothelial Metabolic Control of Insulin Sensitivity Through Resident Macrophages

Medicine, Rheumatology and Immunology, Endocrinology, Life Sciences, Cell Biology, Biochemistry, Immunology,
endothelial cells   glucose metabolism   insulin resistance   resident macrophages   muscle insulin sensitivity  

Endothelial Cells Influence Insulin Sensitivity Through Metabolic Regulation of Resident Macrophages In recent years, metabolic diseases, especially insulin resistance and diabetes, have become significant global health issues. Muscle tissue, being one of the main organs for glucose metabolism in the human body, has its insulin sensitivity closely ...

Lycium Barbarum Polysaccharides Improves Cognitive Functions in ICV-STZ-Induced Alzheimer’s Disease Mice Model by Improving the Synaptic Structural Plasticity and Regulating IRS1/PI3K/AKT Signaling Pathway

Medicine, Medical Laboratory Science, Geriatrics, Neurology, Life Sciences, Biochemistry, Bioengineering, Immunology,
Alzheimer’s disease   ICV-STZ   insulin resistance   neurodegeneration   synapse  

Study on the Improvement of Cognitive Function in ICV-STZ-Induced Alzheimer’s Disease Mouse Model by Lycium Barbarum Polysaccharides Research Background Alzheimer’s disease (AD) is the most common neurodegenerative disease of the central nervous system, characterized by progressive cognitive impairment, memory loss, personality changes, and emotion...