Preoperative Stereotactic Radiotherapy to Prevent Pancreatic Fistula in High-Risk Patients Undergoing Pancreatoduodenectomy (FIBROPANC): Prospective Multicentre Phase II Single-Arm Trial

Medicine, Hepatobiliary System, Anesthesiology, Gastroenterology, Oncology,
pancreatic fistula   stereotactic radiotherapy   pancreatoduodenectomy   high-risk patients   fibrosis   safety   efficacy  

Pancreaticoduodenectomy is a common surgery for treating tumors of the pancreas and surrounding organs, but postoperative pancreatic fistula (POPF) is one of its major complications, especially in high-risk patients, where the incidence of POPF can be as high as 50%. POPF not only increases hospitalization time and medical costs but can also lead t...

Corticosteroids Combined with Low-Dose Methotrexate in the Treatment of Pemphigus Vulgaris: A Retrospective Cohort Study

Medicine, Rheumatology and Immunology, Life Sciences, Immunology,
corticosteroids   methotrexate   pemphigus vulgaris   efficacy   safety  

Academic Background Pemphigus Vulgaris (PV) is a rare and severe autoimmune blistering disease characterized by a chronic course accompanied by multiple complications and side effects from medication. Currently, guidelines in many countries recognize systemic corticosteroids (CS) and rituximab (RTX) as first-line treatments for PV. However, due to ...

Revumenib for KMT2A-Rearranged Relapsed or Refractory Acute Leukemia: Efficacy and Safety

Medicine, Hematology, Oncology,
Revumenib   KMT2A-rearranged   acute leukemia   relapsed   refractory   safety   efficacy  

Academic Background Acute leukemia is a malignant hematologic disease caused by genetic mutations in hematopoietic cells, characterized by a block in differentiation during hematopoiesis and uncontrolled cellular proliferation. Among these, KMT2A gene rearrangements (KMT2A-rearranged, KMT2Ar) occur in up to 10% of acute leukemias in children and ad...

Demonstration of Group-Level and Individual-Level Efficacy Using Time-to-Event Designs for Clinical Trials of Antiseizure Medications

Medicine, Medical Laboratory Science, Neurology,
antiseizure medications   clinical trials   time-to-event design   efficacy   epilepsy   safety   randomized controlled trial  

Time-to-Event Design in Clinical Trials and Efficacy of Anti-Epileptic Drugs at Group and Individual Levels Background The significance of anti-epileptic drugs (ASM) in treating refractory epilepsy cannot be ignored. However, the current parallel assignment, randomized, placebo-controlled trial (RCT) designs have been in use for many years, requiri...

Safety & Efficacy of a Robotic Hip Exoskeleton on Outpatient Stroke Rehabilitation

Medicine, Orthopedics, Neurology, Life Sciences, Bioengineering,
stroke rehabilitation   exoskeleton   gait training   outpatient   safety   efficacy  

Safety and Efficacy: The Impact of Robotic Hip Exoskeleton on Outpatient Stroke Rehabilitation Background Stroke is the leading cause of disability among adults in the United States, with up to 80% of stroke survivors experiencing gait impairments, such as reduced walking speed, endurance, and asymmetrical gait, thereby limiting their ability to wa...

Efficacy-Effectiveness Analysis on Survival in a Population-Based Real-World Study of BRAF-Mutated Metastatic Colorectal Cancer Patients Treated with Encorafenib-Cetuximab

Medicine, Basic Medical Sciences, Gastroenterology, Oncology, Life Sciences, Genetics,
BRAF mutation   metastatic colorectal cancer   Encorafenib   Cetuximab   real-world study   survival rate   efficacy  

Efficacy-Effectiveness Analysis of Encorafenib-Cetuximab Treatment in Patients with Oncogene-Mutated Metastatic Colorectal Cancer: A Cohort Study Research Background With the advancement of personalized medicine, targeted therapy has become an important means to treat various cancers. In metastatic colorectal cancer (mCRC), the combination of encor...