Dopaminylation of endothelial TPI1 suppresses ferroptotic angiocrine signals to promote lung regeneration over fibrosis

Medicine, Respiratory System, Life Sciences, Cell Biology, Biochemistry, Immunology,
dopaminylation   endothelial cells   TPI1   ferroptosis   lung regeneration   fibrosis   metabolism  

Dopamine Modification of TPI1 Inhibits Ferroptosis Signaling in Vascular Endothelial Cells, Promoting Lung Regeneration and Inhibiting Fibrosis Background The regenerative capability of the lung enables it to restore its original functional tissue after injury. However, if this regenerative process is disrupted, it often leads to maladaptive repair...

DDX5 Inhibits Hyaline Cartilage Fibrosis and Degradation in Osteoarthritis via Alternative Splicing and G-Quadruplex Unwinding

Medicine, Orthopedics, Basic Medical Sciences, Geriatrics,
osteoarthritis   hyaline cartilage   fibrosis   DDX5   alternative splicing   G-quadruplex  

The Novel Mechanism of DDX5 in Inhibiting Hyaline Cartilage Fibrosis and Degradation in Osteoarthritis Background Osteoarthritis (OA) is a chronic degenerative disease characterized mainly by the degradation, degeneration, and osteophyte formation of joint cartilage. Hyaline cartilage fibrosis is often considered the end-stage lesion of OA, leading...

Attenuation of Fibroblast Activation and Fibrosis by Adropin in Systemic Sclerosis

Medicine, Rheumatology and Immunology, Basic Medical Sciences, Life Sciences, Biochemistry,
systemic sclerosis   fibroblast   fibrosis   Adropin   TGFB   fibrosis therapy   RNA sequencing  

Reducing Fibroblast Activation and Fibrosis in Systemic Sclerosis through Adropin Fibrotic diseases of the skin and other organs have become significant socioeconomic challenges in modern society, and current treatment options are limited. This background for this study seeks to address the problem of fibrosis in Systemic Sclerosis (SSc), with the ...