Persistent Expression of Amphiregulin (AREG) in Intermediate Alveolar Stem Cells Drives Progressive Pulmonary Fibrosis Background Fibrotic diseases are a leading cause of up to 45% of deaths in developed countries. Pulmonary fibrosis is a disease characterized by alveolar structure damage and impaired gas exchange, with Idiopathic Pulmonary Fibrosi...

Dopamine Modification of TPI1 Inhibits Ferroptosis Signaling in Vascular Endothelial Cells, Promoting Lung Regeneration and Inhibiting Fibrosis Background The regenerative capability of the lung enables it to restore its original functional tissue after injury. However, if this regenerative process is disrupted, it often leads to maladaptive repair...

The Novel Mechanism of DDX5 in Inhibiting Hyaline Cartilage Fibrosis and Degradation in Osteoarthritis Background Osteoarthritis (OA) is a chronic degenerative disease characterized mainly by the degradation, degeneration, and osteophyte formation of joint cartilage. Hyaline cartilage fibrosis is often considered the end-stage lesion of OA, leading...

Reducing Fibroblast Activation and Fibrosis in Systemic Sclerosis through Adropin Fibrotic diseases of the skin and other organs have become significant socioeconomic challenges in modern society, and current treatment options are limited. This background for this study seeks to address the problem of fibrosis in Systemic Sclerosis (SSc), with the ...