Phase Ib Trial of Neoadjuvant Oncolytic Virus OrienX010 and Toripalimab in Resectable Acral Melanoma

Medicine, Rheumatology and Immunology, Basic Medical Sciences, Oncology, Life Sciences, Bioengineering, Immunology, Microbiology,
acral melanoma   neoadjuvant therapy   oncolytic virus   PD-1 inhibitors   tumor microenvironment   recurrence-free survival   safety  

Neoadjuvant Oncolytic Virus OrienX010 Combined with PD-1 Inhibitor Toripalimab for Resectable Acral Melanoma: Phase Ib Clinical Trial Background Acral melanoma (AM) is a highly aggressive subtype of melanoma with a high incidence in the Chinese population, accounting for approximately 40% of melanoma cases. Despite advances in melanoma treatment, c...

Demonstration of Group-Level and Individual-Level Efficacy Using Time-to-Event Designs for Clinical Trials of Antiseizure Medications

Medicine, Medical Laboratory Science, Neurology,
antiseizure medications   clinical trials   time-to-event design   efficacy   epilepsy   safety   randomized controlled trial  

Time-to-Event Design in Clinical Trials and Efficacy of Anti-Epileptic Drugs at Group and Individual Levels Background The significance of anti-epileptic drugs (ASM) in treating refractory epilepsy cannot be ignored. However, the current parallel assignment, randomized, placebo-controlled trial (RCT) designs have been in use for many years, requiri...

Safety & Efficacy of a Robotic Hip Exoskeleton on Outpatient Stroke Rehabilitation

Medicine, Orthopedics, Neurology, Life Sciences, Bioengineering,
stroke rehabilitation   exoskeleton   gait training   outpatient   safety   efficacy  

Safety and Efficacy: The Impact of Robotic Hip Exoskeleton on Outpatient Stroke Rehabilitation Background Stroke is the leading cause of disability among adults in the United States, with up to 80% of stroke survivors experiencing gait impairments, such as reduced walking speed, endurance, and asymmetrical gait, thereby limiting their ability to wa...

Laser Interstitial Thermal Therapy for First-Line Treatment of Insular Glioma: A Novel Treatment Framework

Medicine, Neurology, Neurosurgery, Medical Imaging, Oncology,
insular glioma   laser interstitial thermal therapy   safety   cytoreductive treatment   surgical management  

Application of Laser Interstitial Thermal Therapy in Insular Gliomas Research Background and Problem Statement The management of insular gliomas has always faced significant surgical challenges. Due to the complex functional and vascular anatomy surrounding the insula, maximally safe resection is highly technically challenging. Removing low-grade a...

Safety and Feasibility Study of Non-Invasive Vagus Nerve Stimulation in Spontaneous Subarachnoid Hemorrhage

Medicine, Neurology, Neurosurgery, Life Sciences, Bioengineering,
non-invasive   vagus nerve stimulation   safety   feasibility   spontaneous subarachnoid hemorrhage  

Application of Non-Invasive Vagus Nerve Stimulation in Spontaneous Subarachnoid Hemorrhage: A Randomized Safety and Feasibility Study Report Spontaneous subarachnoid hemorrhage (SAH) is often accompanied by severe thunderclap headaches, which patients typically describe as the “worst headache of their lives.” The vast majority of patients (90%) con...