Identification of senescent, TREM2-expressing microglia in aging and Alzheimer's disease model mouse brain

Identification of senescent, TREM2-expressing microglia in aging and Alzheimer's disease model mouse brain

Alzheimer’s disease (AD) is an age-related chronic neurodegenerative disorder, whose pathological mechanism involves multiple factors, including brain inflammation. Microglia, particularly those expressing the AD risk gene TREM2, are believed to play a crucial role in the development of AD, but their exact contribution has not been fully elucidated...

Assessing the contribution of the chemical exposome to neurodegenerative disease

Assessing the contribution of the chemical exposome to neurodegenerative disease

Assessing the Risks of Chemical Exposures for Neurodegenerative Diseases Introduction In recent years, many environmental chemicals, from solvents to pesticides, have been implicated in the development and progression of neurodegenerative diseases. However, a systematic approach akin to genome-wide association studies, which have identified dozens ...