Research on Quantitative Model for Freezing of Gait in Parkinson’s Patients Background Introduction Parkinson’s Disease (PD) is a common neurodegenerative disease, accompanied by complex motor disorders. In the later stages of Parkinson’s disease, the phenomenon of “Freezing of Gait” (FOG) becomes particularly prominent. FOG refers to a transient p...
Background and Research Motivation Parkinson’s Disease (PD) is a neurodegenerative disorder primarily affecting patients’ motor abilities, leading to tremors, bradykinesia, limb rigidity, and problems with gait and balance. These motor deficits significantly impact patients’ ability to live independently and their quality of life. Statistics predic...
MRI-Guided Staged Bilateral Focused Ultrasound Subthalamotomy for Parkinson’s Disease Background Parkinson’s Disease (PD) is a common neurodegenerative disorder, characterized mainly by motor symptoms such as tremor, rigidity, and bradykinesia. Traditionally, treatments for PD include medication and surgical interventions such as Deep Brain Stimula...
Background Introduction In contemporary neuroscience research, dopamine and serotonin are hypothesized to be crucial neuromodulators guiding social behavior. However, there is a significant lack of understanding regarding the dynamic changes of these neuromodulators during social interactions. Although non-invasive functional neuroimaging methods (...
Parkinson’s Disease (PD) is a neurodegenerative disease primarily characterized by dopaminergic neuron damage. Aside from causing motor disorders, over 80% of Parkinson’s disease patients also suffer from sleep disorders. Fragmented sleep is a common type of sleep disturbance among PD patients. It is associated not only with sleep maintenance insom...
The Opening of the Blood-Brain Barrier in the Nigrostriatal System in Parkinson’s Disease Research Background Parkinson’s disease is a neurodegenerative disorder characterized by the gradual degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to impaired dopaminergic transmission in the striatum. Currently, there are...
This is a large-scale prospective cohort study on depression in patients with Parkinson’s disease (PD). Researchers have used the vast cohort data from the UK Biobank to investigate the temporal association between depression and the onset of PD, the relationship between depression and brain region structure in PD patients, and the impact of depres...
Assessing the Risks of Chemical Exposures for Neurodegenerative Diseases Introduction In recent years, many environmental chemicals, from solvents to pesticides, have been implicated in the development and progression of neurodegenerative diseases. However, a systematic approach akin to genome-wide association studies, which have identified dozens ...