Single-Cell Analysis of Anti-BCMA CAR T Cell Therapy in Patients with Central Nervous System Autoimmunity

Central Nervous System (CNS) autoimmune diseases, such as Neuromyelitis Optica Spectrum Disorders (NMOSD), are inflammatory demyelinating conditions characterized by relapses of optic neuritis and myelitis. Despite significant progress in the treatment of NMOSD, a subset of patients responds poorly to current therapies, with recurrent and difficult...

Neuronal Functional Connectivity is Impaired in a Layer-dependent Manner Near Chronically Implanted Intracortical Microelectrodes in C57BL/6 Wildtype Mice

Layer-Dependent Effects of Chronic Neural Electrode Implants on Neural Functional Connectivity in Mice Introduction This study explores the long-term effects of chronically implanted microelectrodes on neural functional connectivity within the brains of C57BL6 wild-type mice. Implanted intracerebral electrodes enable the recording and electrical st...

Vagus Nerve Stimulation Enhances Remyelination and Decreases Innate Neuroinflammation in Lysolecithin-Induced Demyelination

Comprehensive Academic Report on Scientific Paper Research Background Multiple sclerosis (MS) is an inflammatory and degenerative disease of the central nervous system (CNS), affecting approximately 2.8 million people worldwide. The pathological mechanisms of this disease are mainly related to autoimmune-mediated demyelination and axonal transectio...

An Autoantibody Signature Predictive for Multiple Sclerosis

An Autoantibody Signature Predictive for Multiple Sclerosis

Predictive Autoantibody Signature for Multiple Sclerosis Academic Background and Research Significance Multiple Sclerosis (MS) is a chronic inflammatory autoimmune disease that primarily affects the white matter of the central nervous system (CNS). Previous studies have mostly suggested that T cells play a major role in the pathogenesis of MS. Howe...

Identification of senescent, TREM2-expressing microglia in aging and Alzheimer's disease model mouse brain

Identification of senescent, TREM2-expressing microglia in aging and Alzheimer's disease model mouse brain

Alzheimer’s disease (AD) is an age-related chronic neurodegenerative disorder, whose pathological mechanism involves multiple factors, including brain inflammation. Microglia, particularly those expressing the AD risk gene TREM2, are believed to play a crucial role in the development of AD, but their exact contribution has not been fully elucidated...