Single-Nucleus Sequencing Reveals Enriched Expression of Genetic Risk Factors in ALS-Sensitive Neurons

Publication of a New Study on ALS Neurodegeneration in 《Nature Aging》 Throughout human history, numerous mysterious diseases have posed significant challenges for scientific research. Among these, Amyotrophic Lateral Sclerosis (ALS), a progressive neurodegenerative disease, is known for the gradual loss of muscle function and disability it causes. ...

Comprehensive Genomic and Transcriptomic Characterization of High-Grade Gastro-Entero-Pancreatic Neoplasms

Comprehensive Genomic and Transcriptomic Characterization of High-Grade Gastro-Entero-Pancreatic Neoplasms

Research Report on Comprehensive Genomic and Transcriptomic Characteristics of High-Grade Gastro-Entero-Pancreatic Neuroendocrine Tumors Research Background High-grade gastro-entero-pancreatic neuroendocrine neoplasms (HG GEP-NENs) are a heterogeneous group of malignant tumors characterized by neuroendocrine differentiation. According to WHO 2019 [...

Time of Exercise Differentially Impacts Bone Growth in Mice

Differential Effects of Exercise Timing on Skeletal Growth in Mice Introduction Skeletal growth is crucial for adult height and bone health. Studies have shown that exercise can effectively increase bone density, but the optimal exercise timing remains unclear. This study aimed to investigate the optimal exercise timing by comparing the effects of ...

Transcriptomic Sex Differences in Postmortem Brain Samples from Patients with Psychiatric Disorders

Transcriptomic Sex Differences in Postmortem Brain Samples from Patients with Psychiatric Disorders

Analysis of Gender Differences in Transcriptomes of Postmortem Brain Tissues from Psychiatric Patients Background Gender differences in psychiatric patients are a well-documented phenomenon. Disorders such as Schizophrenia (SCZ), Bipolar Disorder (BD), and Autism Spectrum Disorder (ASD) all exhibit significant gender differences. However, the speci...