Obesity Intensifies Sex-specific Interferon Signaling to Selectively Worsen Central Nervous System Autoimmunity in Females

Obesity Intensifies Sex-specific Interferon Signaling to Selectively Worsen Central Nervous System Autoimmunity in Females

Obesity Aggravates Female Central Nervous System Autoimmune Diseases Through Sex-Specific Interferon Signaling In recent years, the rising incidence of central nervous system (CNS) autoimmune diseases in females has garnered widespread attention. Obesity, as a potential environmental risk factor, has gradually become a research hotspot. The latest ...

Sex Differences in the Risk of Stroke Associated with Traditional and Non-Traditional Factors in a US Cohort of People with HIV Infection

Study on Gender Differences and Stroke Risk Among HIV-Infected Individuals Background Individuals with HIV infection may face a higher risk of stroke, particularly women. However, understanding of whether the influence of various factors on cerebrovascular risk in this population differs by gender and whether these differences contribute to variati...

Microglia Undergo Sex-Dimorphic Transcriptional and Metabolic Rewiring During Aging

The Role of Microglia in Neuroinflammation: Metabolic and Gender Differences in Aging Research Background Aging is a major risk factor for neurodegenerative diseases such as Alzheimer’s Disease (AD) and Parkinson’s Disease. Even healthy aging is accompanied by a decline in cognitive function. Previous research has indicated that microglia undergo s...

Transcriptomic Sex Differences in Postmortem Brain Samples from Patients with Psychiatric Disorders

Transcriptomic Sex Differences in Postmortem Brain Samples from Patients with Psychiatric Disorders

Analysis of Gender Differences in Transcriptomes of Postmortem Brain Tissues from Psychiatric Patients Background Gender differences in psychiatric patients are a well-documented phenomenon. Disorders such as Schizophrenia (SCZ), Bipolar Disorder (BD), and Autism Spectrum Disorder (ASD) all exhibit significant gender differences. However, the speci...

Characterization of Human Shoulder Joint Stiffness Across 3D Arm Postures and Its Sex Differences

Characterization of Human Shoulder Joint Stiffness Across 3D Arm Postures and Its Sex Differences

Three-Dimensional Postural Characteristics and Gender Differences in Human Shoulder Joint Stiffness Research Background The shoulder joint is one of the most complex joints in the human structure. Its stability is crucial for the effective control of arm movement, including the natural control of distal joints like the elbow and wrist, as well as f...