D1R-5-HT2AR Uncoupling Alleviates Depressive Behaviors Through HDAC Signaling Research Background Major depressive disorder (MDD) is a globally prevalent and life-threatening mental illness, closely associated with poor physical health. Despite the availability of various treatments, including medications and psychotherapy, many patients exhibit po...
Preliminary Research Report on the Relationship between CYP46A1 Polymorphism and Suicide Risk Research Background Suicide, defined as the intentional act of ending one’s own life, is a major global public health issue. The incidence of suicide is higher among individuals with Major Depressive Disorder (MDD). However, the role of cholesterol in suic...
Research Report on FMOD Alleviating Depressive Behavior After Traumatic Brain Injury Traumatic Brain Injury (TBI) is a global health issue with far-reaching impacts, causing not only brain dysfunction but also often leading to mental disorders. One of the most common mental illnesses following TBI is depression, affecting approximately 25-50% of TB...
Computational Modeling of Prefrontal-Cingulate Coupling: Exploring Its Role in Balancing Emotion and Cognition Academic Background In recent years, emotional processing and cognitive control, which are crucial for maintaining normal social behavior and executive function, have attracted widespread attention. This study explores how the balance betw...
The Role of BMAL1 in LPS-Induced Depressive Behavior and Related “Inflammatory Storm” Introduction According to the 2019 Global Burden of Disease Study, mental disorders are listed as one of the top 10 causes of global burden, with depression being a major contributor. Over 350 million people worldwide suffer from depression, making it the most com...
Using fMRI to Guide TMS Target Selection: Reliability and Sensitivity of 3T and 1.5T fMRI Metrics [DOI: 10.1007/s12021-024-09667-5], published in Neuroinformatics Background Introduction The early application of functional magnetic resonance imaging (fMRI) mainly focused on inferring cognitive processes. However, modern medicine is gradually extend...
Spatio-Temporal Responses of Emotional Conflict and Psychiatric Correlation in Adolescent Epilepsy Patients Research Background Epilepsy patients often experience comorbid mental disorders such as depression and anxiety, which negatively impact their quality of life. Emotional regulation is a critical cognitive process that is frequently impaired i...
The Regulatory Mechanism of Central Complement C3a Receptor on LPS-Induced Depressive-Like Behavior Introduction With the increasing number of depression patients globally, major depressive disorder (MDD) has become one of the leading causes of disability worldwide. The symptoms, treatment effects, and biological correlations of depression exhibit ...
This is a large-scale prospective cohort study on depression in patients with Parkinson’s disease (PD). Researchers have used the vast cohort data from the UK Biobank to investigate the temporal association between depression and the onset of PD, the relationship between depression and brain region structure in PD patients, and the impact of depres...