Enhancing Angiogenesis and Osseointegration through a Double Gyroid Ti6Al4V Scaffold with Triply Periodic Minimal Surface

Materials Science, Metallic Materials, Medicine, Orthopedics, Life Sciences, Bioengineering,
bone repair   angiogenesis   triply periodic minimal surface   titanium alloy scaffold   osseointegration   porous structure   cell proliferation  

Application of Double Gyroid Titanium Alloy Scaffolds Based on Triply Periodic Minimal Surface Structures in Bone Repair Academic Background Bone defect repair is a significant challenge in the field of orthopedics, especially in cases of critical-size bone defects caused by trauma, tumors, inflammation, and other diseases. Currently, the commonly ...

Lactate Secreted by Glycolytic Conjunctival Melanoma Cells Attracts and Polarizes Macrophages to Drive Angiogenesis in Zebrafish Xenografts

Medicine, Ophthalmology, Oncology, Life Sciences, Immunology,
angiogenesis   conjunctival melanoma   macrophages   glycolysis   lactate   zebrafish model  

Academic Background Conjunctival Melanoma (COM) is a rare but potentially lethal ocular cancer, particularly when metastasis occurs, with limited treatment options. Although current treatments for primary conjunctival melanoma are relatively effective, once metastasis occurs, patient survival rates drop significantly, with most patients surviving l...

Oscillatory Contractile Forces Refine Endothelial Cell-Cell Interactions for Continuous Lumen Formation Governed by Heg1/CCM1

Medicine, Cardiovascular System, Life Sciences, Cell Biology, Biophysics,
oscillatory contractile forces   endothelial cells   Heg1   CCM1   lumen formation   cell-cell interactions   angiogenesis  

Academic Background The formation and maintenance of vascular networks are critical processes in embryonic development and tissue regeneration, involving the regulation of various biophysical forces. Endothelial cells (ECs) play a central role in angiogenesis and vasculogenesis, with the contractile forces of the cytoskeleton (actomyosin contractil...

Maternal Serum PLGF Associates with 3D Power Doppler Ultrasound Markers of Utero-Placental Vascular Development in the First Trimester: The Rotterdam Periconception Cohort

Medicine, Obstetrics and Gynecology,
placenta   angiogenesis   spiral artery remodeling   angiogenic factors   sFlt-1   preeclampsia  

Academic Background The placenta plays a critical role in health and disease during pregnancy, and its development and function directly impact pregnancy outcomes. The early development of the utero-placental vasculature is essential for ensuring normal placental function, while abnormal vascular development is closely associated with placenta-rela...

Enhanced Epithelial-Mesenchymal Transition Signatures Are Linked with Adverse Tumor Microenvironment, Angiogenesis, and Worse Survival in Gastric Cancer

Medicine, Gastroenterology, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
epithelial-mesenchymal transition   gastric cancer   gene set variation analysis   survival rate   tumor microenvironment   angiogenesis  

Enhanced EMT Characteristics Associated with Unfavorable Tumor Microenvironment, Angiogenesis, and Poorer Prognosis in Gastric Cancer Academic Background Epithelial-Mesenchymal Transition (EMT) is an extremely important mechanism that promotes the metastasis of cancer cells. However, despite its apparent importance, the clinical significance of EMT...

Disturbance in Cerebral Blood Microcirculation and Hypoxic-Ischemic Microenvironment are Associated with the Development of Brain Metastasis

Medicine, Neurology, Neurosurgery, Oncology, Life Sciences, Immunology,
cerebral blood microcirculation   hypoxic-ischemic microenvironment   brain metastasis   angiogenesis   ANG-2   VEGF   anti-angiogenic therapy  

Microcirculatory Disorders of Cerebral Blood Flow and the Hypoxic-Ischemic Microenvironment Related to Brain Metastasis Development Background and Research Motivation Brain metastasis (BM) is an increasing challenge in oncology due to its severe impact on neurological function, limited treatment options, and resulting poor prognosis. BM develops th...