Engineering Selective Gene Drives to Steer Tumor Evolution to Counteract Drug Resistance As tumors evolve, targeted therapies against cancer often fail due to the evolution of drug resistance. This study demonstrates a way to manipulate tumor evolution repeatedly to design therapeutic opportunities, even in the presence of genetic heterogeneity. We...

This study was published in the journal Nature Biotechnology, with the doi 10.1038/s41587-024-02267-3. The corresponding authors are Haihong Chen and Yaohong Wang from East China University of Science and Technology, and the publication date is April 26, 2024. The article investigates the high-yield production of chlorophyll through metabolic engin...

Research on Network Construction and Application of Novel Drug Repositioning Strategies Background During the COVID-19 pandemic, researchers and pharmaceutical companies have been dedicated to developing treatments and vaccines. Drug repositioning, due to its shortcut, is considered a rapid and effective response strategy. Drug repositioning attemp...

Research Background Fluorescence spectroscopy is a widely used method for identifying and quantifying fluorescent substances (fluorophores). However, quantifying the fluorophores of interest becomes challenging when the material contains other fluorophores (baseline fluorophores), especially when the emission spectrum of the baseline is not well-de...

Background In recent years, researchers have shown significant interest in electron-hole crystals within Mott insulators. These types of crystals can achieve quantum excited states, have the potential to support counterflow superfluidity and topological order, and possess long-range quantum entanglement characteristics. However, experimental eviden...

Supramolecular Assembly-Activated Single-Molecule Phosphorescence Resonance Energy Transfer for Near-Infrared Targeted Cell Imaging In recent years, pure organic phosphorescence resonance energy transfer (PRET) research has become a hot topic. In this paper, the authors constructed a single-molecule PRET system with a large Stokes shift (367 nm) an...

Real-Time 3D Analysis of Ionic Colloidal Crystallization Background and Motivation In the study of molecular crystals, the structure is typically identified through scattering techniques, as we cannot directly observe the internal structure. Due to their larger volume, micrometer-sized colloidal particles allow us to observe their crystallization p...

Neuritogenic Glycosaminoglycan Hydrogels Promote Functional Recovery After Severe Traumatic Brain Injury Traumatic brain injury (TBI) is a serious neurological disorder, and the complexity of its treatment has long plagued the medical community. TBI not only leads to immediate loss of neurological function in patients, but also causes long-term tis...

Mobile Iodine Capture Technology Enhances the Stability of Perovskite Solar Cells Background Introduction Perovskite Solar Cells (PSCs) are considered promising candidates for future photovoltaic power generation due to their high efficiency and low cost. However, the stability issues of perovskite materials themselves, particularly photolysis and ...

Using Generative Cellular Automata to Study the Chiral Morphogenesis of Gold Background and Objectives Chirality is ubiquitous in nature and can be transferred and amplified between systems through specific molecular interactions and multi-scale couplings. However, the mechanisms of chiral formation and the critical steps during the growth process ...