Late-Stage Deuteration and Tritiation through Bioinspired Cooperative Hydrogenolysis

Academic Background Hydrogenolysis, a fundamental chemical reaction that breaks chemical bonds through the addition of molecular hydrogen, is widely used in the upgrading of biomass, petroleum, and other feedstocks into high-value chemicals and fuels. Additionally, hydrogenolysis plays a crucial role in the pharmaceutical and fine chemical industri...

Room-Temperature Epitaxy of α-CH3NH3PbI3 Halide Perovskite by Pulsed Laser Deposition

Academic Background Metal Halide Perovskites (MHPs) have garnered significant attention in the field of photovoltaics due to their unique optoelectronic properties. In recent years, these materials have also been widely investigated for applications in light-emitting diodes, lasers, photodetectors, and spintronics. Despite notable progress in solut...

Atomic-Scale Insights into Topotactic Transformations in an Extra-Large-Pore Zeolite Using Time-Resolved 3D Electron Diffraction

Academic Background Zeolites are microporous materials with regular channel structures, widely used in catalysis, adsorption, and ion exchange. Due to their unique pore structures and chemical properties, zeolites hold significant application value in petrochemicals, environmental protection, and energy storage. However, the synthesis and structura...

Electrochemical Lithium Recycling with Electricity Generation

Electrochemical Lithium Recycling with Electricity Generation

Academic Background With the global transition to a low-carbon society, the demand for lithium-ion batteries (LIBs) as an important energy storage technology is rapidly increasing. However, the limited availability of lithium resources and the disposal of spent batteries have become pressing issues. Traditional lithium recycling methods, such as py...

Targeting ADAR1 with a Small Molecule for the Treatment of Prostate Cancer

Academic Background Prostate cancer (PCA) is one of the most common malignancies in men, particularly in Western countries, where it is the second leading cause of cancer-related deaths among males. Although androgen signaling therapy is effective in the initial treatment of prostate cancer, most patients eventually relapse, and there is currently ...

Molecular Mechanism of the Arrestin-Biased Agonism of Neurotensin Receptor 1 by an Intracellular Allosteric Modulator

Academic Background G protein-coupled receptors (GPCRs) are the most abundant family of cell surface receptors in the human body and are also the most common targets of FDA-approved drugs. GPCRs play a crucial role in the treatment of various diseases, including pain, diabetes, cardiovascular diseases, and cancer. However, drug development targetin...

Blue Carbon Cycling in the Coastal Areas of Qatar

Research Background Global climate change, particularly global warming, has exerted immense pressure on the global carbon cycle. As a significant carbon sink, the ocean absorbs large amounts of carbon dioxide (CO₂), leading to ocean acidification, which adversely affects marine organisms reliant on carbonate minerals. Coastal wetlands, such as inte...

GutBugDB: A Web Resource to Predict the Human Gut Microbiome-Mediated Biotransformation of Biotic and Xenobiotic Molecules

In recent years, the significant role of the human gut microbiota (HGM) in the metabolism of drugs and nutrients has gradually been recognized. The gut microbiota not only affects the bioavailability of orally administered drugs but also participates in the biotransformation of drugs and bioactive molecules through its metabolic enzymes, thereby in...

The Crucial and Versatile Roles of Bacteria in Global Biogeochemical Cycling of Iodine

Iodine (I) is a trace element of significant importance to human health and the environment. It is a major component of human thyroid hormones, such as thyroxine (T4) and triiodothyronine (T3), directly influencing thyroid function. However, approximately 1.9 billion people worldwide are affected by Iodine Deficiency Disorder (IDD), with symptoms i...

Speciation-Dependent Molecular Mechanism of Electron Transfer from the c-Type Cytochrome MtrC to U(VI)-Ligand Complexes

Uranium (U) is a radioactive element widely present in the environment, primarily existing in its hexavalent (U(VI)) and tetravalent (U(IV)) oxidation states. Under oxidizing conditions, U(VI) is the dominant stable form, while under reducing conditions, U(VI) can be reduced to U(IV). This reduction process can occur through abiotic pathways (e.g.,...