Compensation or Preservation? Different Roles of Functional Lateralization in Speech Perception of Older Non-Musicians and Musicians

Medicine, Geriatrics, Neurology, Medical Imaging,
functional lateralization   speech perception   aging   musical training experience   auditory processing   cognitive reserve  

The Impact of Music Training on Language Perception in Older Adults Under Global Aging Challenges Research Background As global population aging accelerates, the decline in language perception ability of older adults in noisy environments has become a notable issue. Older adults, even with normal hearing, often encounter the “cocktail party problem...

Microglia Undergo Sex-Dimorphic Transcriptional and Metabolic Rewiring During Aging

Medicine, Geriatrics, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology,
microglia   aging   Alzheimer's disease   sex differences   metabolic reprogramming   neuroprotection   inflammation  

The Role of Microglia in Neuroinflammation: Metabolic and Gender Differences in Aging Research Background Aging is a major risk factor for neurodegenerative diseases such as Alzheimer’s Disease (AD) and Parkinson’s Disease. Even healthy aging is accompanied by a decline in cognitive function. Previous research has indicated that microglia undergo s...

A Bayesian Multiplex Graph Classifier of Functional Brain Connectivity Across Diverse Tasks of Cognitive Control

Medicine, Medical Laboratory Science, Neurology, Medical Imaging, Life Sciences, Bioengineering,
aging   Bayesian statistics   functional brain connectivity   multiplex graph classification   variable selection  

Functional Brain Connectivity Research Using Bayesian Multiplex Graph Classifier Research Background and Problem Statement In recent years, research on cognitive control in the elderly has garnered increasing attention, especially against the backdrop of accelerating population aging. Understanding cognitive functions in the elderly becomes particu...

Small extracellular vesicles from young plasma reverse age-related functional declines by improving mitochondrial energy metabolism

Medicine, Basic Medical Sciences, Geriatrics, Life Sciences, Biochemistry,
young plasma   small extracellular vesicles   mitochondrial energy metabolism   aging   functional decline   proteomics   PGC-1α  

Small Extracellular Vesicles in Young Plasma Reverse Age-Related Functional Decline by Improving Mitochondrial Energy Metabolism Background In recent years, research on heterochronic parabiosis has revealed significant regenerative effects of young blood on elderly tissues. However, the specific regenerative mechanisms are not fully understood. Thi...

Aging Promotes Metabolic Dysfunction-Associated Steatotic Liver Disease by Inducing Ferroptotic Stress

Aging Promotes Metabolic Dysfunction-Associated Steatotic Liver Disease by Inducing Ferroptotic Stress

Medicine, Hepatobiliary System, Geriatrics,
aging   ferroptosis   metabolic dysfunction   steatotic liver disease   liver degeneration   diabetes   obesity  

Research Review on Aging-Exacerbated Metabolic Dysfunction-Related Lipid Liver Diseases Academic Background As the aging population increases, metabolic diseases induced by aging are becoming a severe public health challenge. The liver, being the primary metabolic organ, requires special attention to its functional disorders during aging. Studies h...

Nature of Epigenetic Aging from a Single-Cell Perspective

Medicine, Geriatrics, Life Sciences, Cell Biology, Biochemistry, Genetics,
epigenetic clocks   DNA methylation   single-cell analysis   aging   multiomics data   stochastic changes   gene expression  

Research on the Essence of Epigenetic Aging from a Single-Cell Perspective Research Background As biological research progresses, scientists have discovered that changes in DNA methylation (DNAm) constitute one of the most reliable predictors of age—known as the epigenetic clock. However, the mechanisms underlying what these clocks precisely measur...