Design of Four-Component Protein Nanocages through Programmed Symmetry Breaking Academic Background Protein nanocages are highly symmetric protein assemblies widely used in vaccine development, drug delivery, and nanomaterial design. In nature, viruses often construct complex structures through symmetry breaking, particularly in high triangulation ...

Research on Growth-Based Monolithic 3D Integration of Single-Crystal 2D Semiconductors Academic Background With the rapid development of the modern electronics industry, three-dimensional (3D) integration technology has gradually become an important means to enhance the performance of electronic devices. Traditional two-dimensional (2D) integrated ...

MINFLUX Nanoscopy in Biological Tissue: Breaking the Resolution Barrier of Fluorescence Microscopy Academic Background Fluorescence microscopy plays a crucial role in biological research, but its resolution is limited by the diffraction barrier, typically around 200 nanometers. In recent years, the development of super-resolution microscopy (SR) te...

Protective Effect of Doxycycline-Loaded Calcium Phosphate Nanoparticles on LPS-Induced Neuroinflammation in Mice In the field of neuroscience research, neuroinflammation is an important pathological feature of many neurological diseases. Neuroinflammation is a complex response of the central nervous system (CNS) to various damaging triggers (such a...

Nanopolymer Targeting NF-κB and NLRP3 Reduces Neuroinflammation and Enhances Cognitive Function in Aging and Tauopathy Research Background Aging is a major risk factor for cognitive decline and most neurodegenerative diseases, such as Alzheimer’s disease (AD). These cognitive declines are closely related to the pathological aggregation of Tau prote...

Research on Interferometric Scattering Microscopy and Spatial Coherence Control for Multiparticle Tracking Background Introduction Interferometric Scattering (iSCAT) microscopy has demonstrated unparalleled performance in the field of label-free optical imaging, especially in the detection and imaging of isolated nanoparticles and molecules. Howeve...

Numerical Analysis of Rectangular Open-Channel PCF Biosensor Embedded with TiO2-Au-MXene for Brain Tumor Diagnosis Academic Background and Problem Statement In recent years, the development of cost-effective and highly reliable biosensors has become a research hotspot. These sensors aim to detect minute concentrations of analytes and cover a wide a...

Supramolecular Assembly-Activated Single-Molecule Phosphorescence Resonance Energy Transfer for Near-Infrared Targeted Cell Imaging In recent years, pure organic phosphorescence resonance energy transfer (PRET) research has become a hot topic. In this paper, the authors constructed a single-molecule PRET system with a large Stokes shift (367 nm) an...

Real-Time 3D Analysis of Ionic Colloidal Crystallization Background and Motivation In the study of molecular crystals, the structure is typically identified through scattering techniques, as we cannot directly observe the internal structure. Due to their larger volume, micrometer-sized colloidal particles allow us to observe their crystallization p...

Using Generative Cellular Automata to Study the Chiral Morphogenesis of Gold Background and Objectives Chirality is ubiquitous in nature and can be transferred and amplified between systems through specific molecular interactions and multi-scale couplings. However, the mechanisms of chiral formation and the critical steps during the growth process ...