Neoadjuvant Oncolytic Virus OrienX010 Combined with PD-1 Inhibitor Toripalimab for Resectable Acral Melanoma: Phase Ib Clinical Trial Background Acral melanoma (AM) is a highly aggressive subtype of melanoma with a high incidence in the Chinese population, accounting for approximately 40% of melanoma cases. Despite advances in melanoma treatment, c...

Use of Transcranial Oscillatory Stimulation to Reduce Cybersickness in Virtual Reality Background and Motivation Virtual Reality (VR) technology is increasingly integrated into fields such as work, healthcare, and entertainment. However, approximately 95% of VR users experience symptoms known as Cybersickness (CS), characterized by nausea, dizzines...

Developing a Novel Erythrocyte-MHC-I Conjugate for Cancer Treatment: A Revolutionary Immunotherapy Research Background: Traditional Roles and Newly Discovered Potential Erythrocytes, or red blood cells, are the most abundant cells in the human body, comprising approximately 70% of total cell count in adults. Traditionally recognized for their role ...

Crossing the Blood–Brain Barrier: Study on Adipose-Derived Stem Cells as Carriers for Pro-Apoptotic Oncolytic Myxoma Virus in the Treatment of Murine Glioblastoma Background and Objective Glioblastoma (GBM) is among the most invasive and aggressive brain tumors, characterized by high recurrence rates and poor prognosis. Despite multimodal intervent...

Cotton Population-Level DNA Methylation Polymorphism Study Reveals Epigenomic Contributions to Complex Traits Background and Research Motivation In recent decades, genome and genetic diversity have been extensively studied through genome-wide association studies (GWAS), providing a theoretical foundation for understanding crop trait variations. How...

Deep Learning-Driven Protein Design: Generating Functional Protein Sequences Using Conditional Diffusion Models Proteins are at the core of life sciences research and applications, offering countless possibilities due to their diversity and functional complexity. With advancements in deep learning technologies, protein design has reached a new pinn...

Deciphering the Topological Landscape of Glioma: A Study Based on a Network Theory Framework Glioma stem cells (GSCs) are recognized as key factors in glioma recurrence and treatment resistance, making them an important focus for new therapeutic approaches. However, the limited understanding of the role of GSCs in the hierarchy of glioma has sparke...

Stem Cell Transplantation Extends the Reproductive Lifespan of Naturally Aging Cynomolgus Monkeys Background of the Study The ovary is a crucial organ for female reproduction and health, responsible for producing oocytes and secreting sex hormones. As women age, ovarian reserves gradually decline, eventually leading to menopause, which brings about...

Study of Somite Formation Model Based on Microfluidic System Background and Research Motivation The formation of somites plays a crucial role in vertebrate embryonic development, significantly influencing the layout and functionality of the embryonic musculoskeletal system. Somite formation involves the segmentation of bilateral presomitic mesoderm...

Epitope Prime Editing Shields Hematopoietic Cells from CD123 Immunotherapy: A Novel Therapeutic Strategy for Acute Myeloid Leukemia Research Background and Problem Statement Acute Myeloid Leukemia (AML) is a malignant blood disease characterized by the abnormal differentiation of myeloid hematopoietic stem and progenitor cells (HSPCs). Its incidenc...