Introduction to Cadence: A Neuroinformatics Tool for Supervised Calcium Events Detection

A New Breakthrough in Neuroinformatics: Research Report on Cadence Tool for Calcium Event Detection Background Introduction Calcium imaging technology has revolutionized the study of neuron ensembles, providing researchers with a powerful tool to simultaneously visualize and monitor multiple neuronal activities. Calcium imaging utilizes fluorescent...

A Bayesian Multiplex Graph Classifier of Functional Brain Connectivity Across Diverse Tasks of Cognitive Control

Functional Brain Connectivity Research Using Bayesian Multiplex Graph Classifier Research Background and Problem Statement In recent years, research on cognitive control in the elderly has garnered increasing attention, especially against the backdrop of accelerating population aging. Understanding cognitive functions in the elderly becomes particu...

Photogrammetry Scans for Neuroanatomy Education - A New Multi-Camera System: Technical Note

Photogrammetry Scans for Neuroanatomy Education - A New Multi-Camera System: Technical Note

Neuroinformatics Research: 3D Modeling of Neuroanatomy with Multi-Camera System Academic Background The surgical anatomy of the central nervous system, including the skull and spine, has an extremely complex three-dimensional (3D) structure, making it difficult for learners to fully understand the intricate relationships between various structures....

Solving the Pervasive Problem of Protocol Non-Compliance in MRI Using an Open-Source Tool MRQA

MRQA: Addressing the Widespread Problem of MRI Protocol Non-Compliance Background In recent years, large-scale neuroimaging datasets have played a crucial role in studying brain-behavior relationships, such as the Alzheimer’s Disease Neuroimaging Initiative (ADNI), Human Connectome Project (HCP), and Adolescent Brain Cognitive Development (ABCD) st...

High-Dimensional Mapping of Human CEACAM1 Expression on Immune Cells and Association with Melanoma Drug Resistance

The Expression of High-Dimensional Mapping of Human CEACAM1 on Immune Cells and Its Association with Melanoma Drug Resistance Research Background Human Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) is an inhibitory cell surface protein that acts through homophilic and heterophilic ligand binding. The expression of this protein...

First Clinical Investigation of Near-Infrared Window IIA/IIB Fluorescence Imaging for Precise Surgical Resection of Gliomas

First Clinical Investigation of Near-Infrared Window IIA/IIB Fluorescence Imaging for Precise Surgical Resection of Gliomas

“IEEE Transactions on Biomedical Engineering” August 2022, Vol. 69, No. 8, First Clinical Study: Application of Near-Infrared Window IIA/IIB Fluorescence Imaging in Precise Glioma Resection Surgery Cao Caiguang, Jin Zeping, Shi Xiaojing, Zhang Zhe, Xiao Anqi, Yang Junying, Ji Nan, Tian Jie (IEEE Member), Hu Zhenhua (IEEE Senior Member) Introduction...

A Numerical Analysis of Rectangular Open Channel Embedded TiO2-Au-MXene Employed PCF Biosensor for Brain Tumor Diagnosis

Numerical Analysis of Rectangular Open-Channel PCF Biosensor Embedded with TiO2-Au-MXene for Brain Tumor Diagnosis Academic Background and Problem Statement In recent years, the development of cost-effective and highly reliable biosensors has become a research hotspot. These sensors aim to detect minute concentrations of analytes and cover a wide a...

Modeling of Glioma Growth with Mass Effect by Longitudinal Magnetic Resonance Imaging

Study of Mathematical Models for Tumor Growth – Exploring Glioma Extension Using Longitudinal Magnetic Resonance Imaging A recent article published in the IEEE Transactions on Biomedical Engineering presents a systematic study on the mathematical modeling and growth patterns of gliomas (glioma). This research was conducted by Birkan Tunç, David A. ...

Comparison of Sonication Patterns and Microbubble Administration Strategies for Focused Ultrasound-Mediated Large-Volume Drug Delivery

Comparison of Acoustic Patterns and Microbubble Delivery Strategies in Large-Volume Drug Delivery Mediated by Focused Ultrasound for Blood-Brain Barrier Opening Background Diffuse Intrinsic Pontine Glioma (DIPG) is the most common and lethal brainstem tumor in children. Due to the usually intact blood-brain barrier (BBB) in DIPG, drug penetration i...

CRISPRi-based Circuits to Control Gene Expression in Plants

CRISPRi-based Circuits to Control Gene Expression in Plants

Academic Background In the field of plant biotechnology, traditional gene manipulation methods focus on producing the desired phenotypes and cellular activities through continuous transgene expression. However, strong continuous promoters may lead to gene silencing, metabolic burdens, or other adverse effects on yield, preventing the full realizati...