HLA-A+ Tertiary Lymphoid Structures with Reactivated Tumor-Infiltrating Lymphocytes Are Associated with a Positive Immunotherapy Response in Esophageal Squamous Cell Carcinoma

In esophageal squamous cell carcinoma (ESCC), immune checkpoint blockade (ICB) therapy has achieved significant clinical benefits. However, the overall response rate to ICB treatment remains low. This study aims to identify biomarkers for ESCC response to ICB therapy and explore their potential clinical relevance. The authors of the paper come from...

Efficacy-Effectiveness Analysis on Survival in a Population-Based Real-World Study of BRAF-Mutated Metastatic Colorectal Cancer Patients Treated with Encorafenib-Cetuximab

Efficacy-Effectiveness Analysis of Encorafenib-Cetuximab Treatment in Patients with Oncogene-Mutated Metastatic Colorectal Cancer: A Cohort Study Research Background With the advancement of personalized medicine, targeted therapy has become an important means to treat various cancers. In metastatic colorectal cancer (mCRC), the combination of encor...

Epigenetic Activation of SOX11 is Associated with Recurrence and Progression of Ductal Carcinoma In Situ to Invasive Breast Cancer

Epigenetic Activation of Sox11 in Recurrence and Progression of Ductal Carcinoma In Situ Background Ductal Carcinoma In Situ (DCIS) is a non-invasive breast cancer characterized by the excessive proliferation of luminal epithelial cells surrounded by myoepithelial cells. DCIS accounts for approximately 25% of breast cancer screenings, and its poten...

Persistence and Enrichment of Dominant T Cell Clonotypes in Expanded Tumor-Infiltrating Lymphocytes of Breast Cancer

Research Report: Dominance and Persistence of T-Cell Clones in Tumor-Infiltrating Lymphocytes during Expansion in Breast Cancer Background Tumor-infiltrating lymphocytes (TILs) are lymphocytes that naturally infiltrate the tumor microenvironment and exhibit reactivity to the tumor. This subject is one of the most actively researched areas in tumor ...

Comprehensive Genomic and Transcriptomic Characterization of High-Grade Gastro-Entero-Pancreatic Neoplasms

Comprehensive Genomic and Transcriptomic Characterization of High-Grade Gastro-Entero-Pancreatic Neoplasms

Research Report on Comprehensive Genomic and Transcriptomic Characteristics of High-Grade Gastro-Entero-Pancreatic Neuroendocrine Tumors Research Background High-grade gastro-entero-pancreatic neuroendocrine neoplasms (HG GEP-NENs) are a heterogeneous group of malignant tumors characterized by neuroendocrine differentiation. According to WHO 2019 [...

A Fully Automated Multimodal MRI-Based Multi-task Learning for Glioma Segmentation and IDH Genotyping

A Fully Automated Multimodal MRI-Based Multi-task Learning for Glioma Segmentation and IDH Genotyping

Research Report on Fully Automated Multimodal MRI Multi-task Learning for Glioma Segmentation and IDH Gene Typing Background of the Study Glioma is the most common primary brain tumor in the central nervous system. According to the World Health Organization (WHO) 2016 classification, gliomas are divided into low-grade gliomas (LGG, grades II and II...

CaNet: Context Aware Network for Brain Glioma Segmentation

CaNet: Context Aware Network for Brain Glioma Segmentation

Context-Aware Network Study Report for Glioma Segmentation Glioma is a common type of adult brain tumor that severely harms health and has a high mortality rate. To provide sufficient evidence for early diagnosis, surgical planning, and postoperative observation, multimodal Magnetic Resonance Imaging (MRI) has been widely applied in this field. The...

Fluorescence Molecular Tomography Based on Group Sparsity Priori for Morphological Reconstruction of Glioma

Report on the Study of Fluorescence Molecular Tomography for Morphological Reconstruction of Glioma Based on Group Sparsity Priors 1. Academic Background and Research Motivation Fluorescence Molecular Tomography (FMT) is an important tool in life sciences that allows non-invasive real-time three-dimensional (3D) visualization of fluorescence source...

First Clinical Investigation of Near-Infrared Window IIA/IIB Fluorescence Imaging for Precise Surgical Resection of Gliomas

First Clinical Investigation of Near-Infrared Window IIA/IIB Fluorescence Imaging for Precise Surgical Resection of Gliomas

“IEEE Transactions on Biomedical Engineering” August 2022, Vol. 69, No. 8, First Clinical Study: Application of Near-Infrared Window IIA/IIB Fluorescence Imaging in Precise Glioma Resection Surgery Cao Caiguang, Jin Zeping, Shi Xiaojing, Zhang Zhe, Xiao Anqi, Yang Junying, Ji Nan, Tian Jie (IEEE Member), Hu Zhenhua (IEEE Senior Member) Introduction...

A Numerical Analysis of Rectangular Open Channel Embedded TiO2-Au-MXene Employed PCF Biosensor for Brain Tumor Diagnosis

Numerical Analysis of Rectangular Open-Channel PCF Biosensor Embedded with TiO2-Au-MXene for Brain Tumor Diagnosis Academic Background and Problem Statement In recent years, the development of cost-effective and highly reliable biosensors has become a research hotspot. These sensors aim to detect minute concentrations of analytes and cover a wide a...