Combining Biological Aging and Genetic Susceptibility to Identify High-Risk Populations for Venous Thromboembolism Academic Background Venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), is the third most fatal cardiovascular disease globally. The incidence of VTE is closely related to age, particularly i...

Robust Engraftment of Acute Myeloid Leukemia (AML) in Humanized Scaffolds Background Acute myeloid leukemia (AML) is a malignant blood disorder that poses significant challenges in treatment and research. Patient-derived xenograft (PDX) models are crucial tools for studying AML, but existing PDX models are often complex and labor-intensive, limitin...

Association Study of Polymorphic Single-Nucleotide Variants in miRNA Genes and Colorectal Cancer Susceptibility Academic Background Colorectal cancer (CRC) is one of the most common malignancies with high incidence and mortality rates worldwide. According to global cancer statistics in 2022, CRC ranks as the third most prevalent cancer, with over 1...

Prognostic Prediction Model for Esophageal Squamous Cell Carcinoma Based on Single-Cell RNA Sequencing and Bulk RNA Sequencing Research Background Esophageal Squamous Cell Carcinoma (ESCC) is one of the most common malignant tumors globally, particularly prevalent in East Asia. Despite existing treatment methods such as surgery, endoscopic resectio...

Causal Relationship Between Gut Microbiota and Parkinson’s Disease Academic Background Parkinson’s Disease (PD) is a common neurodegenerative disorder characterized by motor dysfunction (such as bradykinesia, muscle rigidity, and resting tremors) and non-motor symptoms (such as olfactory impairment, cognitive decline, and sleep disturbances). Altho...

Hemispheric Asymmetry of Myelin Orientation in the Mouse Auditory Cortex Academic Background The mammalian brain exhibits inherent asymmetry, which is particularly evident in the motor system and acoustic communication. For example, both mice and humans show hemispheric differences in auditory processing. This asymmetric organization allows the bra...

Classification Study of Parkinson’s Disease and Cervical Dystonia Academic Background Parkinson’s Disease (PD) and Cervical Dystonia (CD) are two common movement disorders whose pathological mechanisms are closely related to abnormal neuronal activity in the basal ganglia. The basal ganglia are a crucial brain structure for motor control, with the ...

The Role of 5-HT1A Agonist Buspirone in Pain Regulation in Postcolitis Rats Background In recent years, increasing clinical and experimental evidence has shown that the brain’s serotonin (5-HT) system plays a significant role in the pathogenesis of gastrointestinal disorders, such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IB...

Distribution and Function of CB1 Cannabinoid Receptor and VGLUT3 in the Human Cerebral Cortex Background Cannabinoid receptor 1 (CB1) regulates synaptic transmission through presynaptic receptors in nerve terminals, and its physiological roles are of significant clinical relevance. However, the cellular sources and synaptic targets of CB1-expressin...

Effects of Altered Haptic Feedback Gain on Balance and Its Neural Mechanisms Background In daily life, human balance control relies on multiple sensory inputs, including vision, vestibular sensation, and proprioception. Haptic feedback also plays a crucial role in balance control, especially when touching a fixed object, as it significantly reduces...