Exploring the Potential of Fiber Optic Sagnac Interferometer in Non-Contact Elasticity Characterization of Soft Tissues Introduction The mechanical properties of soft tissues are critical to modern medicine and biomedical research. Understanding these properties provides significant insights into structural integrity and potential pathological cond...
Development of Next-Generation Low-Cost Optical Coherence Tomography (OCT) Systems: Advancing Retinal Imaging for Clinical Applications Academic Background Optical Coherence Tomography (OCT) is a non-invasive, high-resolution imaging technology widely used in ophthalmology, particularly for diagnosing retinal diseases. However, existing commercial ...
Super-Resolution Imaging Reveals New Advances in Neural Morphodynamics in Mouse Brains: Dynamic Observations in Head-Fixed Awake Animals Background In the field of neuroscience, understanding the morphological changes and functional dynamics of neurons is key to deciphering how the brain processes information and sustains network plasticity. Despit...
Single-Molecule Dynamic Structural Biology: Breakthrough in Observing DNA-Protein Interactions Using Graphene Background Introduction The intricate and precise interactions between DNA and proteins play a crucial role in fundamental biological functions such as DNA replication, transcription, and repair. However, observing these interaction process...
Overcoming the Preferred-Orientation Problem in Single-Particle Cryo-EM: An Innovative Solution through Deep Learning Background Introduction In recent years, single-particle cryogenic electron microscopy (Single-Particle Cryo-EM) has become a core technique in structural biology due to its ability to resolve the atomic-resolution structures of bio...
Single-Molecule Optical Tweezer Technique Reveals the Binding Mechanism of a Small Molecule Activator and PR65 Protein Academic Background Protein phosphatase 2A (PP2A) is a crucial enzyme in regulating cellular signaling. Its dysfunction is closely associated with various cancers and chronic diseases, such as Alzheimer’s disease and chronic obstru...
Resolving Native GABAA Receptor Structures from the Human Brain: A Breakthrough Study Academic Background GABAA receptors (γ-aminobutyric acid type A receptors) are among the most important inhibitory neurotransmitter receptors in the brain, responsible for regulating fast inhibitory signaling in neurons. These receptors are not only key drug targe...
Oscillatory Transcranial Electrical Stimulation and the Quantitative Features of Phosphene Perception Background Introduction Phosphenes refer to the phenomenon of perceiving light points without any external visual stimuli. This phenomenon holds significant importance in visual neuroscience and consciousness studies, as it helps us understand how ...
Exosomes as Biomarkers for Precision Diagnosis of Lung Cancer Academic Background Lung cancer is one of the leading causes of cancer-related deaths worldwide, with early diagnosis and precision treatment of non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) remaining significant challenges. Although traditional tissue biopsy is co...
Computational Modeling Study on the Construction of Receptive Fields in Midget Ganglion Cells of Primate Retina Academic Background The midget pathway in the primate retina is the foundation for high spatial resolution and color perception in the visual system. A key feature of this pathway is the center-surround organization of the receptive field...