Single-Molecule Dynamic Structural Biology: Breakthrough in Observing DNA-Protein Interactions Using Graphene Background Introduction The intricate and precise interactions between DNA and proteins play a crucial role in fundamental biological functions such as DNA replication, transcription, and repair. However, observing these interaction process...

Overcoming the Preferred-Orientation Problem in Single-Particle Cryo-EM: An Innovative Solution through Deep Learning Background Introduction In recent years, single-particle cryogenic electron microscopy (Single-Particle Cryo-EM) has become a core technique in structural biology due to its ability to resolve the atomic-resolution structures of bio...

Single-Molecule Optical Tweezer Technique Reveals the Binding Mechanism of a Small Molecule Activator and PR65 Protein Academic Background Protein phosphatase 2A (PP2A) is a crucial enzyme in regulating cellular signaling. Its dysfunction is closely associated with various cancers and chronic diseases, such as Alzheimer’s disease and chronic obstru...

Resolving Native GABAA Receptor Structures from the Human Brain: A Breakthrough Study Academic Background GABAA receptors (γ-aminobutyric acid type A receptors) are among the most important inhibitory neurotransmitter receptors in the brain, responsible for regulating fast inhibitory signaling in neurons. These receptors are not only key drug targe...

Oscillatory Transcranial Electrical Stimulation and the Quantitative Features of Phosphene Perception Background Introduction Phosphenes refer to the phenomenon of perceiving light points without any external visual stimuli. This phenomenon holds significant importance in visual neuroscience and consciousness studies, as it helps us understand how ...

Exosomes as Biomarkers for Precision Diagnosis of Lung Cancer Academic Background Lung cancer is one of the leading causes of cancer-related deaths worldwide, with early diagnosis and precision treatment of non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) remaining significant challenges. Although traditional tissue biopsy is co...

Computational Modeling Study on the Construction of Receptive Fields in Midget Ganglion Cells of Primate Retina Academic Background The midget pathway in the primate retina is the foundation for high spatial resolution and color perception in the visual system. A key feature of this pathway is the center-surround organization of the receptive field...

Correlated Variability in the Brain Leads to Highly Suboptimal Sensory Coding Academic Background The brain perceives the world through the activity of neural populations, but it remains unclear whether the computational goal of sensory coding is to support the discrimination of sensory stimuli or to generate an internal model of the sensory world....

The Regulatory Role of Dopamine Receptors in the Thalamic Reticular Nucleus: A Study on Neuronal Excitability and Electrical Synapses Academic Background The Thalamic Reticular Nucleus (TRN) is a crucial inhibitory neuronal network in the brain, responsible for regulating the transmission of sensory information between the thalamus and the cortex. ...

The Chilean Brush-tailed Mouse (Octodon degus) as a New Model for Studying the Visual System Academic Background The study of the visual system has always been an important topic in the field of neuroscience. Traditionally, scientists have used nocturnal or crepuscular rodents (such as hamsters, rats, and mice) as models to study the development an...