Study on Myosin Va-dependent NMDA Receptor Transport Mechanism in Hippocampal Neurons In hippocampal neurons, NMDA receptors (N-Methyl-D-Aspartate Receptor, abbreviated as NMDAR) are a subtype of glutamate receptors, crucial for regulating postsynaptic responses and various brain functions. The number of NMDARs in the postsynaptic region can change...
Background Introduction Sterile neuroinflammation is an important factor driving various neurological diseases. Myelin debris, released during the demyelination process in various neurological diseases (such as stroke, spinal cord injury (SCI), multiple sclerosis (MS), traumatic brain injury (TBI), and neurodegenerative diseases), can act as an inf...
Custom Passive Dynamic Ankle-Foot Orthoses Can Improve Walking Economy and Speed Post-Stroke Background Introduction Stroke is one of the leading causes of long-term disability, affecting over 795,000 individuals annually in the United States. A common post-stroke issue is plantar flexor weakness in the affected limb, impacting the ability to contr...
Coordination of Both Hands and Spinal Cord Neuroregulation: How Transcutaneous Spinal Cord Stimulation Changes the Neural Substrate of Bimanual Actions Background: Humans use their arms in complex ways, often requiring coordination of both hands. Neurological disorders have limited this distinctive feature of the human motor system. Understanding h...
Morphology-Specific Calcium Signaling Characteristics in Human Microglia Background and Research Objectives Microglia are the primary immune cells of the central nervous system (CNS), involved in almost all physiological and pathological processes, including development, synaptic transmission, neuroplasticity, sleep, trauma, glioblastoma, and neuro...
A New Breakthrough in Neuroinformatics: Research Report on Cadence Tool for Calcium Event Detection Background Introduction Calcium imaging technology has revolutionized the study of neuron ensembles, providing researchers with a powerful tool to simultaneously visualize and monitor multiple neuronal activities. Calcium imaging utilizes fluorescent...
Broadband Achromatic Spatial Differential Imaging with Optical Spin-Orbit Coupling Background Introduction In image processing, traditional spatial differentiation is typically accomplished through digital electronic computation. However, many big data applications require real-time and high-throughput image processing, which poses a tremendous cha...
Precision Imaging of Cardiac Function and Infarct Scar Size: A Study with Ultrahigh-Field MRI in Acute and Chronic Porcine Models of Myocardial Infarction Research Background Cardiac magnetic resonance imaging (MRI) is an accurate and highly reproducible technique for assessing cardiac function and volume. In recent years, ultrahigh-field (UHF) MRI...
Inhibition of S6K Reduces Age-Related Inflammation and Extends Lifespan through the Endosomal-Lysosomal System Research Background and Problem Description As organisms age, chronic low-grade inflammation (inflammaging) and declined immune function (immunosenescence) become important pathological foundations of many diseases in the elderly, such as ...
Report on the Study of Fluorescence Molecular Tomography for Morphological Reconstruction of Glioma Based on Group Sparsity Priors 1. Academic Background and Research Motivation Fluorescence Molecular Tomography (FMT) is an important tool in life sciences that allows non-invasive real-time three-dimensional (3D) visualization of fluorescence source...