Inhibition of S6K Reduces Age-Related Inflammation and Extends Lifespan through the Endosomal-Lysosomal System Research Background and Problem Description As organisms age, chronic low-grade inflammation (inflammaging) and declined immune function (immunosenescence) become important pathological foundations of many diseases in the elderly, such as ...
Report on the Study of Fluorescence Molecular Tomography for Morphological Reconstruction of Glioma Based on Group Sparsity Priors 1. Academic Background and Research Motivation Fluorescence Molecular Tomography (FMT) is an important tool in life sciences that allows non-invasive real-time three-dimensional (3D) visualization of fluorescence source...
Near-Infrared Window II Fluorescence Imaging-Guided Surgery Prolongs Progression-Free Survival for High-Grade Glioma Patients Research Background High-grade glioma (HGG) is the most common malignant primary tumor in the central nervous system, with glioblastoma (GBM) having the worst prognosis. To improve the treatment outcomes for GBM patients, in...
Bidirectional Epigenetic Editing Reveals Hierarchies in Gene Regulation Background and Research Motivation In the human genome, the role of non-coding elements such as enhancers in gene regulation is widely recognized. However, current CRISPR interference methods still have some limitations in studying non-coding elements and genetic interactions. ...
Functional Connectivity Across the Brain and Temporally Enhanced Non-neuronal Low-Frequency Oscillation (SLFO) Blood Flow Signal Based on Functional Magnetic Resonance Imaging Scans In the field of neuroscience, a core question is how the brain’s connectivity reconfigures over time to support adaptive functional changes. These dynamically changing ...
Breakthrough in Long-term Live Subcellular Imaging: Study of Confocal Scanning Light-Field Microscopy Research Background Long-term live cell dynamic observation is indispensable in studying physiological pathological processes such as immune response and brain function, requiring high spatiotemporal resolution and low phototoxicity. Existing confo...
Transcriptomics Technology Tracking-Seq Reveals Off-Target Effect Heterogeneity Mediated by CRISPR-Cas9 Research Background With the rapid development of genome editing technologies, the CRISPR-Cas9 system has been widely used in biomedical research due to its high efficiency and ease of operation. However, a significant issue with the CRISPR-Cas9 ...
In the past few decades, with the rapid development of science and technology, human understanding of the immune system has continuously deepened. Among all immune cells, professional phagocytes (such as neutrophils and macrophages) play a crucial role in clearing apoptotic cells, cell debris, and invading pathogens. These cells uptake and engulf f...
Single-Cell Topographical Analysis Reveals Biomechanical Characteristics of Cytotoxic T Cells Introduction In recent years, research on how the immune system functions in different mechanochemical environments has shown that immune cells dynamically alter their shape and exert forces on their surroundings to sense physical parameters and activate i...
Differential Study of GPCR-G Protein Coupling Biosensors Background Introduction G protein-coupled receptors (GPCRs) are important molecules for transmembrane signal transduction, capable of selectively binding to heterotrimeric G proteins composed of Gα, Gβ, and Gγ subunits and regulating various intracellular signaling processes. Studying the fun...