High-Precision Prediction of Protein Fragment Inhibitory Activity: The Application of FragFold Academic Background Protein interactions play a crucial role in cellular life activities, and peptides or protein fragments can regulate protein functions by binding to specific protein interfaces, even acting as inhibitors. Recent developments in high-th...
Academic Background In cell biology, focal adhesions (FAs) are key connection points between cells and the extracellular matrix (ECM), linking integrin receptors to the intracellular actin cytoskeleton. They play a crucial role in cell migration and polarization. Talin is a core protein in focal adhesions that directly connects integrin receptors t...
Study of Visual Behavior in Freely Moving Primates: Development and Application of an Innovative Eye-Tracking System Academic Background The visual system is one of the most extensively studied areas within the primate nervous system, particularly concerning the mechanisms of visual pathways in the cerebral cortex. However, current research on how ...
Spatial Patterning Analysis of Cellular Ensembles (SPACE): Revealing Complex Spatial Patterns in Biological Tissues Academic Background The function of biological tissues depends on the interactions of cells, molecules, and structures in three-dimensional space. Understanding these spatial organization patterns can provide new insights into patholo...
A New Framework for Multi-Trait Rare Variant Analysis: Multistaar Research Background and Problem Statement With the advancement of next-generation sequencing technologies and the decreasing cost of whole-genome sequencing (WGS), researchers can delve deeper into the impact of rare variants on complex human traits. However, single-trait analysis me...
Promoting Healthy Longevity: Implementation Recommendations for the Hevolution Alliance for Aging Biomarkers Initiative Academic Background and Research Motivation With the intensification of global population aging, human life expectancy has significantly increased, but the growth in healthy life expectancy (i.e., years lived in good health) has b...
Research Background and Problem Introduction Protein O-GlcNAc glycosylation is an important post-translational modification that plays a critical role in cellular metabolic plasticity. Aberrant O-GlcNAc glycosylation levels have been observed in various cancers, including endometrial cancer (EC), a common malignancy in women. However, clinical char...
Human Hand Movement Control—Differences in Kinematics Between Functional Object Manipulation and Grasping Actions Academic Background The functionality of the human hand plays a crucial role in daily life, particularly through its dexterity, which allows us to use tools to complete various complex tasks. However, millions of people lose hand functi...
Modular Brain-Machine Interface: Innovative Breakthrough in Neurorecording, Neurostimulation, and Drug Delivery Academic Background Brain-Machine Interfaces (BMIs) are crucial tools in neuroscience and clinical medicine, enabling interactions between the brain and the external world through charge, matter, and information exchange. They are widely ...
Research on an Ultra-Low Power Carbon Dioxide Sensor for Real-Time Breath Monitoring Academic Background Carbon dioxide (CO₂) is a critical gas produced during human respiration, and its real-time monitoring is essential for diagnosing and treating respiratory diseases (e.g., asthma, dyspnea, sleep apnea) as well as metabolic disorders. Traditional...