Exploring the Applications of Single-Molecule Systems for Detection and Monitoring of Plasma-Circulating Nucleosomes and Oncoproteins in Diffuse Midline Glioma Research Background and Problem Overview Diffuse Midline Glioma (DMG) is a highly aggressive brain tumor primarily affecting children with extremely high mortality rates. This type of tumor ...
The Potential of Oncolytic Cytomegaloviruses Expressing EGFR-Retargeted Fusogenic Glycoprotein Complex and Drug-Controlled IL-12 in Cancer Immunotherapy Background and Objectives In recent years, cancer viroimmunotherapy has emerged as a promising research focus in the field of cancer treatment. This therapy leverages viruses to infect tumor cells,...
Using Liposomal Doxorubicin Neoadjuvant Chemotherapy to Enhance Immune Protection of Tumor Membrane Antigen-Based Nanovaccine Background and Significance Surgical resection remains the primary treatment for solid tumors, but postoperative tumor recurrence and metastasis continue to be major challenges. A promising emerging strategy in personalized ...
Research on a New Platform for Tumor-Specific Drug Delivery Targeting the Warburg Effect Cancer remains a global health challenge. Traditional cancer treatments, such as chemotherapy and radiotherapy, often come with significant side effects due to their inability to distinguish between tumor tissues and healthy tissues, leading to damage in the la...
Targeting CD70 with iPSC-Derived CAR-NK Cell Therapy Background and Objectives of the Study Over the past decade, cellular therapy for cancer has revolutionized traditional treatment concepts by introducing the idea of a “living drug.” In particular, chimeric antigen receptor T cell (CAR-T) therapy has drastically improved the efficacy of immunothe...
Research Report: Mitochondrial Uncouplers Inhibit E2F1 Activity and Prostate Cancer Growth Background Prostate cancer (PC) is the most common cancer and the second leading cause of cancer-related deaths among men in the United States. In 2024, an estimated 299,010 American men will be diagnosed with prostate cancer, and 35,250 will die from the dis...
Polarimetric Imaging Technology Assisting Intraoperative Peripheral Nerve Identification: A Cutting-Edge Study Peripheral nerves play a crucial role in the sensory and control networks of the human body, and their integrity and proper functioning are essential to our quality of life. Unfortunately, accidental peripheral nerve injuries are not uncom...
Challenging Skin Pigmentation Bias: Application of Time-Domain Near-Infrared Spectroscopy in Tissue Oximetry Background and Motivation In recent years, optical technologies have been increasingly utilized in medical diagnostics and therapies. However, varying levels of skin pigmentation (which depend on melanin concentration in the skin) can signif...
Demonstration of Femtosecond Laser Induced Refractive Index Change in Silk-Fibroin Hydrogels: A New Hope for Future Ophthalmic Biocompatible Implants In today’s era of advanced biotechnology and rapid developments in the biomedical field, refractive correction techniques have become a global research hotspot in ophthalmology. However, current corre...
The Combination of Optical Coherence Tomography and Robotics: Current Research and Future Perspectives Academic Background Optical Coherence Tomography (OCT) is a non-invasive, high-resolution optical imaging technique that has been widely used in the field of biomedical imaging since its invention. It provides micrometer-level visualization of tis...