Extreme Compression and Reconstruction of Protein Sequence Space: A Breakthrough Study on EvoAI Background Protein design and optimization have become central challenges in fields like biotechnology, medicine, and synthetic biology. The functions of proteins are determined by their sequences and structures, but this functional sequence space is hig...
ONIX: An Open-Source Platform for Multimodal Neural Recording and Perturbation During Naturalistic Behavior Research Background and Significance In recent years, significant advances have been made in large-scale neural population recording technology and studies on animal behavior in the field of neuroscience. However, these two demands often conf...
Fully Automated Microfluidic Chip-Based Embryo Sexing Technology Academic Background In the egg-laying poultry industry, newly hatched male chicks are often culled immediately after hatching, as they neither lay eggs nor produce high-quality meat. Each year, approximately 372 million male chicks are culled in the European Union. This practice has s...
Development of an Engineered Direct Electron Transfer Enzyme for Continuous Levodopa Monitoring Background Parkinson’s Disease (PD) is a chronic neurodegenerative disease that affects millions of people worldwide. It is characterized by the loss of dopaminergic neurons in the substantia nigra and the presence of α-synuclein aggregations forming Lew...
Early Detection of Uveal Melanoma Using Electrical Impedance Spectroscopy Academic Background Uveal Melanoma (UM) is the most common primary intraocular malignancy in adults, characterized by high aggressiveness, which can lead to vision loss and even life-threatening outcomes. Early detection and timely treatment are crucial for preserving vision ...
Research on the Functional Mapping of Rubisco Enzyme Background Introduction Rubisco (ribulose-1,5-bisphosphate carboxylase/oxygenase) is the most abundant enzyme on Earth, responsible for the carbon dioxide fixation process in photosynthesis. However, Rubisco’s catalytic efficiency is low, and it is prone to side reactions with oxygen, limiting th...
Multiscale Footprints Reveal the Role of Cis-Regulatory Elements in Cell Differentiation and Aging Background Introduction The regulation of gene expression is a key mechanism in cell fate determination and disease development, and cis-regulatory elements (CREs) play a crucial role in this process. CREs dynamically regulate gene expression by bindi...
Establishment of a Personalized Antisense Oligonucleotide (ASO) Screening Platform Based on Patient-Derived Organoids Academic Background In recent years, with the rapid development of genome sequencing technologies, an increasing number of rare genetic diseases have been found to be associated with specific gene mutations. Antisense oligonucleotid...
Optimization-Based Conformal Path Planning for In Situ Bioprinting in Complex Skin Defect Repair Academic Background The skin, as the largest organ in the human body, plays a crucial role in protecting the body from external harm. However, the high prevalence of skin injuries such as burns and chronic ulcers worldwide has led to an increasing deman...
Research on 3D Bioprinted Scaffolds Promoting Bone Regeneration Academic Background In recent years, the incidence of head and craniofacial injuries has significantly increased due to the development of industries and transportation, as well as the frequent occurrence of wars and conflicts. These injuries and related treatments (such as decompressi...