Relmβ Sets the Threshold for Microbiome-Dependent Oral Tolerance

The Key Role of RELMβ in Food Allergy Academic Background Food allergy (FA) is a common immune system disorder, particularly prevalent among children. The occurrence of food allergy is associated with abnormal immune responses to food antigens, especially the dysregulation of type 2 immune responses. Type 2 immune responses are typically defense me...

Electrospun Polyvinyl Alcohol Fibres Incorporating an Antimicrobial Gel for Enzymatically Controlled Reactive Oxygen Species Release

Study on Antimicrobial Gel Combined with Electrospun Polyvinyl Alcohol Fibers for Enzymatically Controlled Reactive Oxygen Species Release Academic Background The skin is the body’s first line of defense against infections, and the presence of wounds can compromise this barrier, increasing the risk of infection. With the rise of antibiotic resistan...

Investigating the Validity of MCIM and SCIM Phenotypic Methods in Screening Pseudomonas aeruginosa Isolates Producing IMP, VIM, and NDM Metallo-Beta-Lactamases Isolated from Burn Wounds

Investigating the Validity of mCIM and sCIM Phenotypic Methods in Screening Pseudomonas aeruginosa Isolates Producing IMP, VIM, and NDM Metallo-β-Lactamases from Burn Wounds Background Pseudomonas aeruginosa is a Gram-negative bacterium widely found in the environment, particularly in hospital settings. It is the second most common pathogen causing...

Aztreonam-Avibactam: A New Combination with Activity Against Multidrug-Resistant Klebsiella pneumoniae Complex

Aztreonam-Avibactam Activity Against Multidrug-Resistant Klebsiella pneumoniae Complex Background The Klebsiella pneumoniae complex (KPC) is a group of opportunistic pathogens that pose a serious threat to public health. In recent years, the infection rate of multidrug-resistant (MDR) Klebsiella pneumoniae has significantly increased, leading to ex...

Cryptoic Acids A and B, Benzene-Containing Polyketides, and Cyclocryptamide, a Modified Diketopiperazine, from an Actinomycete of the Genus Cryptosporangium

Novel Benzene-Containing Polyketides and Modified Diketopiperazine from Actinomycete of the Genus Cryptosporangium Academic Background Microbial natural products hold significant value in drug development, particularly actinomycetes, which provide a rich source of various therapeutic compounds, such as aminoglycosides, macrolides, and tetracyclines...

Therapeutic Potential of Isoallolithocholic Acid in Methicillin-Resistant Staphylococcus aureus Peritoneal Infection

Therapeutic Potential of Isoallolithocholic Acid in Methicillin-Resistant Staphylococcus aureus Peritoneal Infection Background Methicillin-resistant Staphylococcus aureus (MRSA), discovered in 1961, has become one of the most common antibiotic-resistant bacteria worldwide. MRSA infections can lead to fatal sepsis, pneumonia, and high rates of skin...

Activity of Cefiderocol in Combination with Tetracycline Analogues Against Carbapenem-Resistant Acinetobacter baumannii

Study on the Combination of Cefiderocol and Tetracycline Analogues for Treating Carbapenem-Resistant Acinetobacter baumannii Academic Background Carbapenem-resistant Acinetobacter baumannii (CR-AB) is one of the major pathogens responsible for hospital-acquired infections, often leading to severe conditions such as ventilator-associated pneumonia, ...

Inhibitors of Acetohydroxyacid Synthase as Promising Agents Against Non-Tuberculous Mycobacterial Diseases

New Hope for the Treatment of Non-Tuberculous Mycobacterial Diseases—Research on Acetohydroxyacid Synthase Inhibitors Academic Background Non-tuberculous mycobacteria (NTM) infections have become an important cause of pulmonary diseases worldwide in recent years, especially among immunocompromised populations. The treatment of NTM infections faces ...

Novobiocin primarily targets ParE in Neisseria gonorrhoeae

Novobiocin Primarily Targets ParE in Neisseria gonorrhoeae Background Neisseria gonorrhoeae is a Gram-negative bacterium that causes gonorrhea, one of the most common sexually transmitted infections worldwide. According to the World Health Organization (WHO), there were 82.3 million new cases of gonorrhea among people aged 15–49 in 2020. However, t...

Differential Gene Expression Analysis Shows That Cephalosporin Resistance is Intrinsic to Clostridioides difficile Strain 630

Research on Cephalosporin Resistance in C. difficile Background Clostridioides difficile infection (CDI) is one of the most common hospital-acquired infections in the United States, leading to a significant number of hospitalizations and even deaths annually. CDI not only poses a threat to patient health but also imposes a substantial economic burd...