Research on Network Construction and Application of Novel Drug Repositioning Strategies Background During the COVID-19 pandemic, researchers and pharmaceutical companies have been dedicated to developing treatments and vaccines. Drug repositioning, due to its shortcut, is considered a rapid and effective response strategy. Drug repositioning attemp...

Metagenomic Next-Generation Sequencing as an Alternative to Procalcitonin in Guiding Antibiotic Use in Patients with Acute Necrotizing Pancreatitis and Fever Background and Research Objectives Acute pancreatitis (AP) is one of the leading causes of emergency hospital admissions for digestive system diseases, with significant medical resource utiliz...

Interaction Between Gut Microbiota and Colonic Enteroendocrine Cells Regulates Host Metabolism Research Background Obesity is a major health issue in the 21st century and a significant factor contributing to various adverse health consequences such as diabetes, fatty liver disease, and cardiovascular diseases. Therefore, exploring the biological me...

Microbial Metabolite Ethylamine as FXR Agonist Promotes Polycystic Ovary Syndrome in Female Mice I. Research Background and Objectives Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder affecting 6%-20% of women of reproductive age worldwide. Symptoms of PCOS include hyperandrogenemia, ovarian dysfunction, and polycystic ...

Inducing and Optimizing VRC01-like Broadly Neutralizing Antibodies in Mouse Models with mRNA-LNP Background Introduction In recent years, the importance of acquiring broadly neutralizing antibodies (bnAbs) has been increasingly recognized in vaccine development, particularly in the field of HIV (Human Immunodeficiency Virus) vaccine research. The H...

Hybrid Hydrogel-Magnetic Driven Capsule for Automatic Intestinal Microbiome Sampling Academic Background The gut microbiome is composed of a large and diverse community of microorganisms that significantly impact human health, including conditions such as cancer, diabetes, and inflammatory bowel disease (IBD). Current methods for studying the gut m...

Oncolytic Mineralized Bacteria May Be Used for Tumor Immunotherapy via Local Injection Research Background As a novel cancer treatment method, bacteria-based cancer immunotherapy has a long history dating back to the late 19th century when heated, inactivated bacteria were used to treat sarcomas. Initial trials found that these bacteria could trigg...

Linking microbial evolution and ecological restructuring in the human gut Background: The human gut harbors hundreds of microbial species that interact with each other in a complex ecological network. Recent studies have shown that gut microbes can evolve within human-relevant timescales, but little is known about how this evolution impacts (or is ...