Novel Benzene-Containing Polyketides and Modified Diketopiperazine from Actinomycete of the Genus Cryptosporangium Academic Background Microbial natural products hold significant value in drug development, particularly actinomycetes, which provide a rich source of various therapeutic compounds, such as aminoglycosides, macrolides, and tetracyclines...

Therapeutic Potential of Isoallolithocholic Acid in Methicillin-Resistant Staphylococcus aureus Peritoneal Infection Background Methicillin-resistant Staphylococcus aureus (MRSA), discovered in 1961, has become one of the most common antibiotic-resistant bacteria worldwide. MRSA infections can lead to fatal sepsis, pneumonia, and high rates of skin...

Study on the Combination of Cefiderocol and Tetracycline Analogues for Treating Carbapenem-Resistant Acinetobacter baumannii Academic Background Carbapenem-resistant Acinetobacter baumannii (CR-AB) is one of the major pathogens responsible for hospital-acquired infections, often leading to severe conditions such as ventilator-associated pneumonia, ...

New Hope for the Treatment of Non-Tuberculous Mycobacterial Diseases—Research on Acetohydroxyacid Synthase Inhibitors Academic Background Non-tuberculous mycobacteria (NTM) infections have become an important cause of pulmonary diseases worldwide in recent years, especially among immunocompromised populations. The treatment of NTM infections faces ...

Novobiocin Primarily Targets ParE in Neisseria gonorrhoeae Background Neisseria gonorrhoeae is a Gram-negative bacterium that causes gonorrhea, one of the most common sexually transmitted infections worldwide. According to the World Health Organization (WHO), there were 82.3 million new cases of gonorrhea among people aged 15–49 in 2020. However, t...

Research on Cephalosporin Resistance in C. difficile Background Clostridioides difficile infection (CDI) is one of the most common hospital-acquired infections in the United States, leading to a significant number of hospitalizations and even deaths annually. CDI not only poses a threat to patient health but also imposes a substantial economic burd...

Identification of Nanaomycin A and Its Analogs as Functional Inhibitors of the Type IX Secretion System in Porphyromonas gingivalis Using a Novel Screening Method Academic Background Porphyromonas gingivalis is a Gram-negative anaerobic bacterium recognized as one of the primary pathogens in chronic periodontitis. Beyond periodontal diseases, P. gi...

Discovery and Research of the New Antibiotic Thiazoplanomicin Academic Background In recent years, the issue of antibiotic resistance has become increasingly severe, particularly with Neisseria gonorrhoeae (gonococcus), a common sexually transmitted pathogen. Gonococcus can rapidly develop drug resistance, rendering traditional antibiotics such as ...

Antimicrobial Activity of Novel α/β Hybrid Peptides Against Methicillin-Resistant Staphylococcus aureus (MRSA) Research Background With the widespread use and misuse of antibiotics, multi-drug resistance (MDR) has become a major global public health threat. Particularly, ESKAPE pathogens (including Enterococcus faecium, Staphylococcus aureus, Klebs...

Causal Relationship Between Gut Microbiota and Parkinson’s Disease Academic Background Parkinson’s Disease (PD) is a common neurodegenerative disorder characterized by motor dysfunction (such as bradykinesia, muscle rigidity, and resting tremors) and non-motor symptoms (such as olfactory impairment, cognitive decline, and sleep disturbances). Altho...