Interaction Between the Gut Microbiota and Colonic Enteroendocrine Cells Regulates Host Metabolism

Interaction Between the Gut Microbiota and Colonic Enteroendocrine Cells Regulates Host Metabolism

Medicine, Endocrinology, Gastroenterology, Life Sciences, Biochemistry, Bioengineering, Microbiology,
gut microbiota   colonic enteroendocrine cells   host metabolism   obesity   gut-brain axis   glutamate  

Interaction Between Gut Microbiota and Colonic Enteroendocrine Cells Regulates Host Metabolism Research Background Obesity is a major health issue in the 21st century and a significant factor contributing to various adverse health consequences such as diabetes, fatty liver disease, and cardiovascular diseases. Therefore, exploring the biological me...

The Microbial Metabolite Agmatine Acts as an FXR Agonist to Promote Polycystic Ovary Syndrome in Female Mice

Medicine, Obstetrics and Gynecology, Endocrinology, Gastroenterology, Life Sciences, Biochemistry, Microbiology,
Polycystic Ovary Syndrome   Agmatine   FXR   Gut Microbiome   Hormones   Insulin Resistance  

Microbial Metabolite Ethylamine as FXR Agonist Promotes Polycystic Ovary Syndrome in Female Mice I. Research Background and Objectives Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder affecting 6%-20% of women of reproductive age worldwide. Symptoms of PCOS include hyperandrogenemia, ovarian dysfunction, and polycystic ...

mRNA-LNP Prime Boost Evolves Precursors Toward VRC01-Like Broadly Neutralizing Antibodies in Preclinical Humanized Mouse Models

Medicine, Infectious Diseases, Rheumatology and Immunology, Life Sciences, Immunology, Microbiology,
mRNA vaccines   broadly neutralizing antibodies   preclinical humanized mouse models   HIV   immunology   lipid nanoparticles  

Inducing and Optimizing VRC01-like Broadly Neutralizing Antibodies in Mouse Models with mRNA-LNP Background Introduction In recent years, the importance of acquiring broadly neutralizing antibodies (bnAbs) has been increasingly recognized in vaccine development, particularly in the field of HIV (Human Immunodeficiency Virus) vaccine research. The H...

Hybrid Hydrogel-Magnet Actuated Capsule for Automatic Gut Microbiome Sampling

Hybrid Hydrogel-Magnet Actuated Capsule for Automatic Gut Microbiome Sampling

Materials Science, Organic Polymeric Materials, Life Sciences, Bioengineering, Microbiology,
hydrogel   magnetic mechanism   medical robotics   wireless capsule   automatic sampling   gut microbiome  

Hybrid Hydrogel-Magnetic Driven Capsule for Automatic Intestinal Microbiome Sampling Academic Background The gut microbiome is composed of a large and diverse community of microorganisms that significantly impact human health, including conditions such as cancer, diabetes, and inflammatory bowel disease (IBD). Current methods for studying the gut m...

Oncolytic Mineralized Bacteria as Potent Locally Administered Immunotherapeutics

Medicine, Basic Medical Sciences, Oncology, Life Sciences, Cell Biology, Immunology, Microbiology,
oncolytic bacteria   immunotherapy   mineralized   tumor microenvironment   antitumor   immune response  

Oncolytic Mineralized Bacteria May Be Used for Tumor Immunotherapy via Local Injection Research Background As a novel cancer treatment method, bacteria-based cancer immunotherapy has a long history dating back to the late 19th century when heated, inactivated bacteria were used to treat sarcomas. Initial trials found that these bacteria could trigg...

Eco-evolutionary feedbacks in the human gut microbiome

Medicine, Gastroenterology, Life Sciences, Genetics, Microbiology,
human gut microbiota   eco-evolutionary feedbacks   community dynamics  

Linking microbial evolution and ecological restructuring in the human gut Background: The human gut harbors hundreds of microbial species that interact with each other in a complex ecological network. Recent studies have shown that gut microbes can evolve within human-relevant timescales, but little is known about how this evolution impacts (or is ...