Research on Cephalosporin Resistance in C. difficile Background Clostridioides difficile infection (CDI) is one of the most common hospital-acquired infections in the United States, leading to a significant number of hospitalizations and even deaths annually. CDI not only poses a threat to patient health but also imposes a substantial economic burd...

Identification of Nanaomycin A and Its Analogs as Functional Inhibitors of the Type IX Secretion System in Porphyromonas gingivalis Using a Novel Screening Method Academic Background Porphyromonas gingivalis is a Gram-negative anaerobic bacterium recognized as one of the primary pathogens in chronic periodontitis. Beyond periodontal diseases, P. gi...

Discovery and Research of the New Antibiotic Thiazoplanomicin Academic Background In recent years, the issue of antibiotic resistance has become increasingly severe, particularly with Neisseria gonorrhoeae (gonococcus), a common sexually transmitted pathogen. Gonococcus can rapidly develop drug resistance, rendering traditional antibiotics such as ...

Antimicrobial Activity of Novel α/β Hybrid Peptides Against Methicillin-Resistant Staphylococcus aureus (MRSA) Research Background With the widespread use and misuse of antibiotics, multi-drug resistance (MDR) has become a major global public health threat. Particularly, ESKAPE pathogens (including Enterococcus faecium, Staphylococcus aureus, Klebs...

Causal Relationship Between Gut Microbiota and Parkinson’s Disease Academic Background Parkinson’s Disease (PD) is a common neurodegenerative disorder characterized by motor dysfunction (such as bradykinesia, muscle rigidity, and resting tremors) and non-motor symptoms (such as olfactory impairment, cognitive decline, and sleep disturbances). Altho...

Synthesis of Palladium Nanoparticles by Electrode-Respiring Geobacter sulfurreducens Biofilms Research Background In modern industry and environmental science, palladium (Pd) serves as a crucial catalyst widely used in pharmaceuticals, agriculture, and chemical industries. However, traditional methods for synthesizing palladium nanoparticles (Pd NP...

Challenges to Mediterranean Fagaceae Ecosystems Affected by Phytophthora cinnamomi and Climate Change Academic Background The Mediterranean Fagaceae ecosystems, including oak trees (Quercus ilex and Quercus suber) and chestnut trees (Castanea sativa), are vital ecological and economic resources in southern Europe. However, in recent years, these ec...

Forest Tree Virome as a Source of Tree Diseases and Biological Control Academic Background The health of forest ecosystems is crucial for global ecological balance and economic development. However, the health of forest trees is threatened by various pathogens, including fungi, oomycetes, bacteria, viruses, as well as insect and nematode pests. Alt...

Klebsiella pneumoniae-Derived Extracellular Vesicles Impair Endothelial Function by Inhibiting SIRT1 Academic Background Hypertension is a global health issue with a complex pathogenesis involving multiple factors. In recent years, the role of gut microbiota in hypertension has garnered significant attention. Studies have shown that dysbiosis of th...

Staphylococcus Aureus Vesicles Impair Cutaneous Wound Healing Through p38 MAPK-MerTK Cleavage-Mediated Inhibition of Macrophage Efferocytosis Background Introduction Staphylococcus aureus (S. aureus) is one of the primary pathogens causing chronic wound infections, particularly in diabetic patients, with an infection rate as high as 65%. One of the...