Highlights of the Study: Metabolite-Level Regulation of Cyanobacteria Awakening from Dormancy Study Title: “Metabolite-level regulation of enzymatic activity controls awakening of cyanobacteria from metabolic dormancy” Published in Current Biology (January 6, 2025), this study, led by Sofía Doello, involves researchers from the University of Tübing...

Analysis of the Influence of Alkaloids on Frog Skin Microbiomes and Their Metabolic Functions Background and Significance Poison frogs (family Dendrobatidae) are amphibians with unique defense mechanisms, as their skin is rich in alkaloids, which are known for their broad-spectrum antimicrobial properties. However, the ways these alkaloids affect t...

Revolutionary Self-Powered Glucose Monitoring Mechanism: Microengineered Paper-Based Platform with Microbial Spores Academic Background Diabetes is a chronic metabolic disorder characterized by elevated blood glucose levels, which can lead to severe complications such as cardiovascular diseases, retinopathy, kidney failure, and neuropathy. The glob...

Fiber Optics-Based Surface Enhanced Raman Spectroscopy Sensors for Rapid Multiplex Detection of Foodborne Pathogens in Raw Poultry Academic Background Foodborne illnesses are a significant global public health challenge, with Salmonella being one of the leading pathogens causing such diseases. In the United States alone, Salmonella results in 1.35 ...

The Respiratory Microbiome is Linked to the Severity of RSV Infections and the Persistence of Symptoms in Children Academic Background Respiratory Syncytial Virus (RSV) is a leading cause of respiratory infections and hospitalizations in infants. While known risk factors for severe infections include preterm birth, congenital heart disease, and bro...

The Ongoing Evolution of SARS-CoV-2 Drives Escape from mRNA Vaccine-Induced Humoral Immunity Academic Background Since its emergence in late 2019, SARS-CoV-2 has undergone continuous evolution, giving rise to multiple variants. These variants have enhanced their transmissibility and immune evasion capabilities through mutations, particularly agains...

Structure-Guided Development of Selective Caseinolytic Protease P Agonists as Antistaphylococcal Agents Academic Background Staphylococcus aureus is a common Gram-positive pathogen that can cause various human infections, including skin and soft tissue infections. With the widespread dissemination of methicillin-resistant Staphylococcus aureus (MRS...

The Role of the Neonatal Gut Microbiota in the Encephalopathy of Prematurity: A Comprehensive Study Academic Background Premature birth (defined as birth before 37 weeks of gestation) is a common issue globally, affecting approximately 10% of pregnancies. Preterm infants are at risk of abnormal brain development, known as Encephalopathy of Prematur...

Synthetic Biology in Cancer Immunotherapy: Engineering Bacteria to Inhibit IDO Activity and Reprogram CD8+ T Cell Responses Academic Background In recent years, significant progress has been made in cancer immunotherapy, particularly through the activation of T cells to combat tumors. However, metabolic adaptations in the tumor microenvironment (TM...

Cyanobacteria–Probiotics Symbionts for Modulation of Intestinal Inflammation and Microbiome Dysregulation in Colitis Academic Background Inflammatory Bowel Disease (IBD) is a group of chronic inflammatory conditions of the gut, primarily including Crohn’s Disease (CD) and Ulcerative Colitis (UC). The pathogenesis of IBD is complex, involving dysfun...