Quantitative and Dynamic Properties of Nutrient Colimitation in Microbial Populations Academic Background The growth, physiology, and metabolic activity of microorganisms are fundamentally controlled by resource availability. Understanding which resources limit microbial growth and to what extent is not only a core concept in microbiology but also ...
Transport and Energetics of Bacterial Rectification Academic Background In nature, many biological systems rely on the directed motion of microscopic particles to achieve their functions. For example, the unidirectional movement of molecular motors (such as kinesins) along microtubules is crucial for intracellular transport. However, the mechanisms...
Neoadjuvant Oncolytic Virus OrienX010 Combined with PD-1 Inhibitor Toripalimab for Resectable Acral Melanoma: Phase Ib Clinical Trial Background Acral melanoma (AM) is a highly aggressive subtype of melanoma with a high incidence in the Chinese population, accounting for approximately 40% of melanoma cases. Despite advances in melanoma treatment, c...
Background and Research Motivation Amyotrophic Lateral Sclerosis (ALS) is a devastating neurodegenerative disease affecting upper and lower motor neurons, leading to progressive muscle paralysis and eventual death. Currently, no effective treatments can significantly delay or halt ALS progression. While various ALS mouse models (such as those carry...
Gut Microbiota-Derived Indole-3-Acetic Acid (3-IAA) Suppresses High Myopia Progression by Promoting Type I Collagen Synthesis Background High myopia (HM) is a serious vision-threatening ocular condition associated with complications such as glaucoma, cataracts, and macular degeneration. Currently, effective interventions for high myopia are lacking...
Cross-Disciplinary Breakthrough: How Mediator Med23 Regulates Molecular Mechanisms of Neural Myelination Background and Research Objective Myelin is the multilayered membrane structure that wraps around axons in the central nervous system (CNS), and its integrity is crucial for neural signal conduction and overall nervous system function. When myel...
Targeting Chemotherapy-Induced Adaptive Signaling Circuitry for Therapeutic Potential in Pancreatic Cancer Background Introduction Pancreatic ductal adenocarcinoma (PDAC) is an aggressive and lethal cancer, with a five-year survival rate that remains extremely low. Over 80% of patients are diagnosed at an advanced, unresectable stage, where existin...
Report on the Study of Bacterial Toxins Inducing Non-Canonical Migracytosis and Aggravating Acute Inflammation Background and Research Objectives In recent years, the discovery of migrasomes, a new type of membrane structure, has gained significant attention in the scientific community for its role in cell migration and various biological functions...
Influence of Dietary Timing on Circadian Rhythms of Gut Microbiota and Rheumatoid Arthritis Inflammation Background Introduction Rheumatoid Arthritis (RA) is a chronic autoimmune disease characterized by systemic inflammation and progressive joint destruction, severely affecting the quality of life of patients. The inflammation and symptoms of RA p...
Fusobacterium nucleatum Promotes Anti-PD-1 Therapy in Microsatellite-Stable Colorectal Cancer Background Introduction With the rise of immune checkpoint blockade (ICB) therapy, a new dawn has emerged in cancer treatment. However, despite the approval of PD-1 targeting drugs (e.g., Pembrolizumab) for certain types of colorectal cancer (CRC) patients...