Development and External Validation of Prediction Risk Scores (StrISK and NOFA) to Predict Immediate Surgical Need in Adhesive Small Bowel Obstruction: An Observational Prospective Multicentre Study

Background Introduction Adhesive Small Bowel Obstruction (ASBO) is one of the leading causes of emergency admissions, accounting for approximately 60% of all small bowel obstruction cases. ASBO is often caused by postoperative intra-abdominal adhesions, with patients presenting symptoms such as abdominal pain, vomiting, and constipation. While most...

Management of High-Risk Acute Pulmonary Embolism: An Emulated Target Trial Analysis

Target Trial Emulation Analysis for the Management of High-Risk Acute Pulmonary Embolism Background Introduction Acute pulmonary embolism (PE) is a life-threatening cardiovascular disease affecting more than 35 people per 100,000 annually. Approximately 5% of PE patients present with persistent hypotension, cardiogenic shock, or cardiac arrest, oft...

Discussing Expected Long-Term Quality of Life in the ICU: Effect on Experiences and Outcomes of Patients, Family, and Clinicians—A Randomized Clinical Trial

The Impact of Discussing Long-Term Quality of Life Predictions in the ICU on Patients, Families, and Healthcare Professionals Academic Background Patients discharged from the Intensive Care Unit (ICU) often face a range of physical, psychological, and cognitive issues, collectively referred to as Post-Intensive Care Syndrome (PICS). Despite improve...

ESICM Consensus-Based Recommendations for the Management of Very Old Patients in Intensive Care

ESICM Consensus: Management and Challenges of Very Old Patients in Critical Care Academic Background With the global aging population, the proportion of “very old patients” (aged 80 years and above) in intensive care units (ICUs) is rapidly increasing. This group is characterized by functional impairments and a high prevalence of complex multimorbi...

Serum Chloride Concentration and Outcomes in Adults Receiving Intravenous Fluid Therapy

The Relationship Between Serum Chloride Concentration and Intravenous Fluid Therapy Outcomes Background Introduction In the intensive care unit (ICU), intravenous fluid therapy is a common treatment, with “balanced solutions” and 0.9% sodium chloride solution (saline) being the most commonly used fluids. In recent years, multiple randomized control...

Neurocritical Care Organization in Low-Income and Middle-Income Countries

Neurocritical Care Organization in Low- and Middle-Income Countries Academic Background and Problem Statement Neurocritical care (NCC) has rapidly evolved over the past few decades as a distinct subspecialty of critical care medicine. Evidence shows that patients with acute brain injuries have significantly improved outcomes when treated in dedicat...

A 10-Year Mono-Center Study on Patients with Burns ≥70% TBSA: Prediction Model Construction and Multicenter Validation – Retrospective Cohort

Survival Prediction Model Construction and Validation for Patients with Major Burns Background Burns are the sixth leading cause of death from injuries globally, particularly for patients with major burns (≥70% total body surface area, TBSA), who face severe complications and poor prognosis. Despite advancements in burn treatment, there is still a ...

Factors in Initial Anticoagulation Choice in Hospitalized Patients with Pulmonary Embolism

Pulmonary Embolism (PE) Overview Pulmonary Embolism (PE) is a serious medical emergency with an annual incidence of approximately 60 to 120 cases per 100,000 people in North America and Europe. Most patients are diagnosed with PE in the Emergency Department (ED), and hospitalization is required for the majority of U.S. patients. Anticoagulation is ...

Increased Emergency Department Medical Imaging: Association with Short-Term Exposures to Ambient Heat and Particulate Air Pollution

The Relationship Between Climate Change and Emergency Medical Imaging Utilization Academic Background Climate change and related environmental exposures have significantly impacted human health, leading to increased demand for healthcare services. High-temperature exposure and poor air quality are closely associated with increased emergency departm...

Neuroprotection with Glyceryl Trinitrate Post-Endovascular Therapy in Acute Ischemic Stroke: A Pilot Randomized Controlled Trial

Overview of Nitroglycerin-Based Neuroprotection in Acute Ischemic Stroke: A Pilot Randomized Controlled Trial Review Background and Research Objectives Acute ischemic stroke (AIS) is one of the leading global causes of disability and death. Despite the significant improvement in vascular recanalization rates and patient outcomes achieved with moder...