Prehospital Lactate Levels Obtained in the Ambulance and Prediction of 2-Day In-Hospital Mortality in Patients with Traumatic Brain Injury

Research Report Background Overview Traumatic Brain Injury (TBI) is one of the leading causes of permanent disability and death worldwide. These disorders are dynamic and evolving, involving progressive brain injury and pathophysiological changes accompanied by multi-system damage. The severity of TBI is typically assessed using the Glasgow Coma Sc...

circPTP4A2 Promotes Microglia Polarization in Cerebral Ischemic Stroke via miR-20b-5p/YTHDF1/TIMP2 Axis

Academic Report on the Scientific Paper “circPTP4A2 Promotes Microglial Polarization in Ischemic Stroke via the miR-20b-5p/YTHDF1/TIMP2 Axis” Background Introduction Ischemic stroke (IS) is brain tissue necrosis caused by cerebral blood flow obstruction and is the second leading cause of disability and death globally. Current clinical treatment str...

Brain-Derived Exosomal circRNAs in Plasma Serve as Diagnostic Biomarkers for Acute Ischemic Stroke

Brain-Derived Exosomal Circular RNAs in Plasma as Diagnostic Biomarkers for Acute Ischemic Stroke Acute ischemic stroke (AIS), commonly known as stroke, is a serious condition characterized by interrupted blood flow to the brain, resulting in tissue damage and neurological deficits. Early diagnosis is crucial for effective intervention and manageme...

Association between Time to Treatment with Endovascular Thrombectomy and Home-Time after Acute Ischemic Stroke

The Relationship between Treatment Speed of Endovascular Thrombectomy (EVT) for Acute Ischemic Stroke and Patient’s “Time at Home” Stroke is an acute disease with high disability and mortality rates. However, in recent years, the treatment efficacy of acute ischemic stroke has improved significantly with the development of endovascular thrombectomy...

Analysis of Cerebral CT Based on Supervised Machine Learning as a Predictor of Outcome After Out-of-Hospital Cardiac Arrest

Brain CT Analysis as a Tool for Outcome Prediction after Out-of-Hospital Cardiac Arrest: A Supervised Machine Learning Analysis Research Background Out-of-Hospital Cardiac Arrest (OHCA) is one of the leading causes of death in the Western world, with extremely low survival rates, ranging from 3% to 16%. The neurological and overall outcomes after O...

Outcomes of Mechanical Thrombectomy for Acute Ischemic Stroke in Cancer Patients: A Single-Center Experience and Meta-Analysis

Research Report: Mechanical Thrombectomy Outcomes in Acute Ischemic Stroke Patients with Cancer Background Acute ischemic stroke (AIS) caused by large vessel occlusion (LVO) is a severe neurological injury, which is further complicated in cancer patients. Cancer-related stroke mechanisms include a hypercoagulable state, coagulopathies due to tumor-...

Impact of a Deep Learning Sepsis Prediction Model on Quality of Care and Survival

Impact of Deep Learning Sepsis Prediction Model on Nursing Quality and Patient Survival Research Background Sepsis is a systemic inflammatory response caused by infection, affecting approximately 48 million people globally each year, with around 11 million deaths. Due to the heterogeneity of sepsis, early identification often faces significant chal...

Outcomes of Mechanical Thrombectomy for Patients with Stroke Presenting with Low Alberta Stroke Program Early Computed Tomography Score in Early and Late Time Windows

Outcomes of Mechanical Thrombectomy for Stroke Patients with Low Alberta Stroke Program Early CT Score Background Acute ischemic stroke is a life-threatening disease, and large vessel occlusion is one of the major causes of severe disability. Mechanical thrombectomy (MT) has become the standard treatment for acute ischemic stroke, with multiple cli...