Messenger RNA transport on lysosomal vesicles maintains axonal mitochondrial homeostasis and prevents axonal degeneration

Messenger RNA transport on lysosomal vesicles maintains axonal mitochondrial homeostasis and prevents axonal degeneration

Medicine, Basic Medical Sciences, Neurology, Life Sciences, Cell Biology, Biochemistry, Genetics,
messenger RNA   lysosomal vesicles   axonal mitochondria   neurodegeneration   RNA granules  

This study utilized induced pluripotent stem cell (iPSC)-derived neurons to investigate the critical role of lysosome-related vesicles in axonal mRNA transport and mitochondrial homeostasis maintenance. By knocking out BORC subunits (borcs5 or borcs7) to block the entry of lysosome-related vesicles into axons, researchers found that this led to a s...

The transcription factor Meis2 promotes the development of projection neurons during mouse embryonic development by binding to and activating projection neuron-specific enhancers with Dlx5

Medicine, Basic Medical Sciences, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
transcription factor   Meis2   Dlx5   enhancers   projection neurons  

This study investigated the role of the transcription factor Meis2 in regulating the development and differentiation of γ-aminobutyric acid (GABA)ergic neurons during mouse embryonic development. Researchers comprehensively applied techniques such as CRISPR/Cas9 knockdown, single-cell RNA sequencing (scRNA-seq), and lineage tracing, and found that ...

Revealing Endoplasmic Reticulum Stress-Related CAF Subpopulations Associated with Chordoma Progression

Revealing Endoplasmic Reticulum Stress-Related CAF Subpopulations Associated with Chordoma Progression

Medicine, Oncology, Life Sciences, Cell Biology, Immunology, Genetics,
Endoplasmic Reticulum Stress   Cancer-Associated Fibroblasts   Chordoma   Single-Cell RNA Sequencing   Spatial Transcriptomics  

Introduction Chordoma is a rare and locally aggressive mesenchymal tumor, believed to originate from the remnant tissues of the primitive notochord. The incidence of chordoma is approximately 0.8 per million, with a predilection for the sacral and skull base regions. Currently, the optimal treatment strategy is maximal safe surgical resection follo...

NF1 mutation-induced neuronal hyperexcitability drives murine optic glioma growth and can be targeted by lamotrigine treatment

Medicine, Neurology, Oncology, Life Sciences, Immunology, Genetics,
NF1 gene mutation   neuronal hyperexcitability   optic glioma   murine models   lamotrigine treatment  

Title: Treating Low-Grade Optic Pathway Glioma by Inhibiting Neuronal Activity Introduction: Optic pathway glioma (OPG) is a low-grade glioma commonly found in children with neurofibromatosis type 1 (NF1). NF1 is a common neurocutaneous syndrome with an incidence of approximately 1⁄3000. Although OPG is a low-grade tumor, it can lead to serious com...

Radical surgical resection with molecular margins is associated with improved survival in IDH wildtype GBM

Medicine, Basic Medical Sciences, Neurosurgery, Oncology, Life Sciences, Genetics,
glioblastoma   TERT promoter mutation   surgical margin   radical resection   survival  

In this research paper from the journal Neuro-Oncology, the researchers investigated the relationship between the residual tumor cells at the resection margin after surgical removal and the progression-free survival (PFS) and overall survival (OS) in patients with wildtype isocitrate dehydrogenase (IDH wildtype) glioblastoma (GBM). The authors are ...

Eco-evolutionary feedbacks in the human gut microbiome

Medicine, Gastroenterology, Life Sciences, Genetics, Microbiology,
human gut microbiota   eco-evolutionary feedbacks   community dynamics  

Linking microbial evolution and ecological restructuring in the human gut Background: The human gut harbors hundreds of microbial species that interact with each other in a complex ecological network. Recent studies have shown that gut microbes can evolve within human-relevant timescales, but little is known about how this evolution impacts (or is ...