Mechanism of Proton Release during Water Oxidation in Photosystem II Academic Background Photosystem II (PSII) is the only enzyme in nature capable of catalyzing water splitting, a reaction that not only releases oxygen but also provides electrons for biomass synthesis. The water-splitting reaction releases protons into the thylakoid lumen, forming...

Capillary-Driven Self-Assembly of Soft Ellipsoidal Microgels at the Air–Water Interface Research Background The adsorption of colloidal particles at fluid interfaces (such as the air–water interface) induces interfacial deformation, leading to anisotropic interface-mediated interactions and the formation of superstructures. Soft ellipsoidal microge...

Triple Oxygen Isotopes of Lunar Water Reveal Indigenous and Cometary Heritage The origin of water on the Moon has long been a pivotal question in planetary science, especially with the increasing need for water resources in the race to establish lunar bases. Potential sources of lunar water include indigenous lunar components, water production by s...

The Oxygen Isotope Identity of the Earth and Moon with Implications for the Formation of the Moon and Source of Volatiles Academic Background The isotopic similarity between Earth and Moon rocks has long been a significant puzzle in geochemistry and cosmochemistry, contradicting prevailing models of Moon formation, particularly the “Giant Impact Th...

Exploring, Sampling, and Interpreting Lunar Volatiles in Polar Cold Traps Academic Background The permanently shadowed regions (PSRs) at the lunar poles, along with other surface volatile deposits, are critical sampling targets for future human missions to the Moon. These volatiles hold significant scientific value and could potentially shift strat...

Report on ALS Treatment Study: Exploring the Multifaceted Mechanisms of Nebivolol and Donepezil Background and Research Objectives Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease marked by progressive loss of motor neurons in the spinal cord and brain, leading to severe muscle atrophy, functional decline, and eventual death...

Deciphering Antagonist Selectivity of Endothelin Receptors: Insights from Cryo-EM-Based Structural Studies Academic Background Endothelin (ET) is a potent vasoconstrictor peptide that plays a significant role in regulating cardiovascular functions. The endothelin family includes ET-1, ET-2, and ET-3, which regulate vascular tone and cardiovascular ...

Development of Semi-synthetic Guanidino-lipoglycopeptide Antibiotics and Study of Their In Vitro and In Vivo Antibacterial Activities Background With the slowdown in antimicrobial drug development and the rapid increase of resistant strains, antibiotic resistance has become a major threat to human health. Particularly, Gram-positive pathogens such ...

Piplartine Attenuates Aminoglycoside-Induced TRPV1 Activity and Protects from Hearing Loss in Mice Academic Background Hearing loss is a serious global health problem affecting over 400 million people worldwide, according to the World Health Organization. Aminoglycoside antibiotics, while widely used in medicine due to their broad-spectrum antibact...

Sequence-based Functional Metagenomics Reveals New Natural Diversity of Functional COPA Genes in Environmental Microbiomes The natural diversity of functional genes/proteins in environmental microbiomes is an essential component of evolutionary and bioengineering research. To gain a deeper understanding of the diversity of the copper (Cu) resistanc...