Academic Report The incidence of global Invasive Fungal Infections (IFIs) has increased over the past few decades, primarily affecting immunocompromised patients, and these infections are often associated with high mortality and morbidity rates. Aspergillus fumigatus is one of the most common and deadly IFI pathogens. The main obstacles to effectiv...
Introduction This report aims to reveal the recent research findings published by Hui Chen et al. in “Science Translational Medicine”, which explores the application of exogenous Acyl-Coenzyme A Binding Protein (ACBP) in Anorexia Nervosa. Anorexia Nervosa is a prevalent and difficult-to-treat eating disorder that primarily affects adolescents and y...
Study on Macular Degeneration Reveals Inhibitory Effect of Natural Killer Cells on Disease Progression Background Age-related Macular Degeneration (AMD) is the leading cause of irreversible blindness among the elderly globally. With an aging population, the incidence of AMD is significantly increasing. Early features of AMD include the accumulation...
Long-term Functional and Epigenetic Changes in Adult Monocytes Induced by AS01-adjuvanted Vaccine Background: Vaccine adjuvants are widely used to enhance the immune response of vaccines. In particular, the AS01 adjuvant, a key component in several approved vaccines, has demonstrated high immunogenicity and efficacy. AS01 exerts its adjuvant effect...
Introduction In recent years, oligonucleotide-based therapeutic technologies, such as antisense oligonucleotides (ASOs) and small interfering RNAs (siRNAs), have been widely applied in the treatment of various neurological disorders. The basis for their application is that these technologies can selectively regulate target RNA molecules, which are ...
Dengue Virus Research: Impact of Genetic Mutations on Virus Transmission and Discoveries Introduction This study was conducted by Allyson N. X. Choi et al. and published in Science Translational Medicine on July 31, 2024. The research aims to reveal the impact of genetic changes in dengue virus on its transmission ability and disease outbreaks duri...
MGA Deletion Promotes Richter’s Transformation by Regulating Mitochondrial Oxidative Phosphorylation This article mainly focuses on the transformation of chronic lymphocytic leukemia (CLL) into aggressive lymphoma, known as Richter’s Transformation (RT), exploring the function and molecular mechanism of MGA (MAX Gene Associated). MGA is a functiona...
A Study on Self-Amplifying RNA Vaccine for Prevention of Enterovirus D68 Infection and Disease in Clinical Models 1. Background In recent years, rapid response to emerging infectious diseases and vaccine development have received much attention. Particularly, the emergence of the novel coronavirus (SARS-CoV-2) has led to rapid advancement in RNA va...
Research on the Association between Neural Networks and Functional Outcomes in Radiotherapy Patients with Pharyngeal Cancer 1. Paper Background Introduction The incidence of human papillomavirus (HPV)-mediated oropharyngeal squamous cell carcinoma (OPSCC) has significantly increased over the past 40 years, especially among younger populations with ...
Research Background Severe alcoholic hepatitis (ALD) is a fatal form of alcohol-associated liver disease (AALD). The course of ALD is usually accompanied by neutrophil infiltration in the liver, which significantly affects the severity of the condition. However, the specific effects of alcohol on neutrophil function remain unclear. Based on this, i...