A New Method for Scalable Spatial Transcriptomics via Large-Format Microarrays: The Birth of Array-Seq Technology Background and Research Motivation In recent years, spatiomolecular analyses have become pivotal tools in biomedical research and clinical pathology due to their ability to study how the spatial organization of cells and molecules withi...

Spatiotemporal Imprinting of Tissue-Resident Memory CD8 T Cell Diversity Background Tissue-resident memory CD8 T cells (TRM cells) provide long-term immune protection at barrier sites such as the intestine. However, the heterogeneity of TRM cells and the mechanisms underlying their formation remain incompletely understood. Previous studies have ide...

The Key Role of RELMβ in Food Allergy Academic Background Food allergy (FA) is a common immune system disorder, particularly prevalent among children. The occurrence of food allergy is associated with abnormal immune responses to food antigens, especially the dysregulation of type 2 immune responses. Type 2 immune responses are typically defense me...

Mitochondrial Transfer and Immune Evasion Mechanisms in the Tumor Microenvironment Academic Background Tumor cells evade immune system attacks, particularly by T cells, through various mechanisms in the Tumor Microenvironment (TME). Although Immune Checkpoint Inhibitors (ICIs) have achieved significant progress in the treatment of various cancers, ...

Photothermal MXene-Embedded Tannin-Eu³⁺ Particles as In Situ Bacterial Vaccines for Seawater-Immersed Infected Wounds Academic Background Seawater-immersed wounds are prone to severe infections due to the low temperature, high salinity, and bacteria-rich environment, which hinder wound healing. Traditional antibacterial strategies often fail to pro...

Prognostic Prediction Model for Esophageal Squamous Cell Carcinoma Based on Single-Cell RNA Sequencing and Bulk RNA Sequencing Research Background Esophageal Squamous Cell Carcinoma (ESCC) is one of the most common malignant tumors globally, particularly prevalent in East Asia. Despite existing treatment methods such as surgery, endoscopic resectio...

Clinical Analysis of MOG Antibody-Associated Disease Overlapping with Anti-NMDAR Encephalitis Background In recent years, with the in-depth study of autoimmune encephalitis (AE) and demyelinating diseases of the central nervous system (CNS), scientists have identified some rare cases of overlapping syndromes. Among them, the overlap between MOG Ant...

The Role of TDO2 Inhibition in Lung Cancer Immune Evasion Background Introduction Lung cancer is one of the leading causes of cancer-related deaths worldwide, with smoking recognized as a primary cause of its occurrence. Cigarette smoke contains numerous carcinogens, among which benzo[a]pyrene (BAP), a polycyclic aromatic hydrocarbon, has been show...

Exosomes as Biomarkers for Precision Diagnosis of Lung Cancer Academic Background Lung cancer is one of the leading causes of cancer-related deaths worldwide, with early diagnosis and precision treatment of non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) remaining significant challenges. Although traditional tissue biopsy is co...

Magnetic Nanoplatform Based on CD26 Targeting and HSP90 Inhibition for Apoptosis and Ferroptosis-Mediated Elimination of Senescent Cells Academic Background With the intensification of population aging, the accumulation of senescent cells is considered a significant hallmark of aging and age-related diseases. Senescent cells are not only associated...