Effects of Clemizole on Parkinson’s Disease Pathology Induced by α-Synuclein Fibril Formation Background Introduction Parkinson’s Disease (PD) is a typical neurodegenerative disease, mainly associated with mitochondrial dysfunction and oxidative stress. However, current therapeutic approaches targeting these pathological events have not successfull...
Academic Report on the Scientific Paper “circPTP4A2 Promotes Microglial Polarization in Ischemic Stroke via the miR-20b-5p/YTHDF1/TIMP2 Axis” Background Introduction Ischemic stroke (IS) is brain tissue necrosis caused by cerebral blood flow obstruction and is the second leading cause of disability and death globally. Current clinical treatment str...
Inflammasome Activation Regulates Apoptosis and Pyroptosis in Astrocytes under Ischemic Conditions Introduction Ischemic stroke is one of the main mechanisms leading to brain damage, characterized by hypoxia and energy deprivation in local brain regions due to interrupted blood flow. In recent years, research has found that inflammatory responses p...
Clinical Impact of Pharmacogenomic Testing on Antiplatelet Therapy Background Pharmacogenomics (PGx) is changing the use of P2Y12 inhibitors (antiplatelet drugs), which are widely used in the treatment of acute coronary syndrome (ACS), neurovascular problems, and vascular diseases. Among them, clopidogrel is a commonly used P2Y12 inhibitor. This pr...
Genome-wide and Polygenic Risk Score Analysis of High-Risk Human Papillomavirus (hrHPV) Infection in the Cervix Background Cervical high-risk human papillomavirus (hrHPV) infection is the second largest carcinogenic infection globally, accounting for approximately 31.4% of all infection-related cancers (about 690,000 cases out of 2.2 million cancer...
Instant Inclusion: In-depth Analysis of Uncertainties Experienced by Parents of Newborns with Severe Combined Immunodeficiency Research Background Severe Combined Immunodeficiency (SCID) is a rare and potentially fatal genetic disorder. Without timely diagnosis and treatment, patients face life-threatening conditions. In recent years, early identif...
In the field of neuroscience, synaptic organization and plasticity are crucial for cognitive functions such as memory and social behavior. As rare synaptic inhibitory factors, members of the family known as MAM domain-containing glycosylphosphatidylinositol anchor proteins (MDGA) play an important regulatory role in synapse formation by inhibiting ...
Behavioral Characterization of Shank3B Mice Across Both Sexes Research Background Autism Spectrum Disorder (ASD) is a group of complex mental disorders characterized by abnormalities in social interaction and repetitive behaviors. The Shank3B mutant ASD mouse model is widely used in research; however, the behavioral phenotype of this model has not ...
In the field of neuroscience, epilepsy has always been a disease of great concern, with significant challenges remaining in clinical research and treatment. Among these, the issue of secondary epileptogenesis has had a profound impact on academia and clinical treatment. Secondary epileptogenesis refers to the continuous spread of epileptic activity...
In the latest research paper “Chemokine CCL2 Promotes Excitatory Synaptic Transmission in Hippocampal Neurons via GluA1 Subunit Trafficking” published in “Neurosci. Bull.”, researchers from multiple institutions, including the Shanghai Institute of Neuroscience, Chinese Academy of Sciences, and the School of Life Sciences, Peking University, have d...