Induction of Tertiary Lymphoid Structures in Glioma Immunotherapy and Their Anti-Tumor Immune Effects Background Introduction Glioma is a highly malignant brain tumor characterized by limited lymphocyte infiltration in the tumor microenvironment (glioma microenvironment, GME), presenting an “immune desert” state. This characteristic makes glioma in...

Single-Cell and Spatial Transcriptomics Study of Meningeal Solitary Fibrous Tumors Academic Background Meningeal Solitary Fibrous Tumors (SFTs) are rare mesenchymal tumors originating from the meninges of the central nervous system (CNS). Although SFTs are histologically similar to other meningeal tumors (such as meningiomas), their unique clinical...

Review of the Study on the Relationship Between IL-6 Signaling and the Anti-Tumor Activity of TGFβ-Specific T Cells Background and Significance of the Study Interleukin-6 (IL-6) is a pleiotropic cytokine that plays a critical role in inflammation and hematopoiesis. However, its role in the immune system is context-dependent. While it has pro-inflam...

Integrated Single-Cell Analysis Reveals Distinct Epigenetic-Regulated Cancer Cell States and a Heterogeneity-Guided Core Signature in Tamoxifen-Resistant Breast Cancer Academic Background Breast cancer is one of the most common cancers in women, and endocrine therapy (e.g., tamoxifen) is the standard treatment for estrogen receptor α (ER)-positive ...

Exosomal PSM-E Inhibits Macrophage M2 Polarization to Suppress Prostate Cancer Metastasis via the RACK1 Signaling Axis Academic Background Prostate cancer (PCA) is a prevalent cancer among men and the second leading cause of cancer-related deaths. While early-stage prostate cancer can be treated with surgery or radiotherapy, approximately one-third...

The Role of lncRNA-Mediated ceRNA Network in Penile Squamous Cell Carcinoma Academic Background Penile Squamous Cell Carcinoma (PSCC) is a relatively rare but life-threatening malignancy that poses a significant health risk to men, particularly in developing countries. Despite advancements in medical diagnosis and treatment, the overall survival ra...

Multimodal Imaging Study of the Tumor Microenvironment in Colorectal Cancer: Revealing Spatial Heterogeneity Academic Background Colorectal cancer (CRC) remains one of the leading causes of cancer-related mortality worldwide, with its complexity and heterogeneity posing significant challenges for treatment and prognosis prediction. The tumor microe...

Report on the Academic Paper: “Multi-modal Analysis Reveals Tumor and Immune Features Distinguishing EBV-positive and EBV-negative Post-transplant Lymphoproliferative Disorders” Summary The Epstein-Barr virus (EBV) is a widely disseminated gamma-1 herpesvirus that infects approximately 90%-95% of adults globally. While EBV infection is typically as...

Neoadjuvant Oncolytic Virus OrienX010 Combined with PD-1 Inhibitor Toripalimab for Resectable Acral Melanoma: Phase Ib Clinical Trial Background Acral melanoma (AM) is a highly aggressive subtype of melanoma with a high incidence in the Chinese population, accounting for approximately 40% of melanoma cases. Despite advances in melanoma treatment, c...

Inhibitory Fcγ Receptor Deletion Enhances CD8 T Cell Stemness, Increasing Anti-PD-1 Therapy Responsiveness in Glioblastoma Background and Objectives of the Study Glioblastoma (GBM) is an aggressive central nervous system tumor with poor prognosis, and the median survival of patients is only 14.6 months. Despite the significant efficacy of immune ch...