High-Precision Prediction of Protein Fragment Inhibitory Activity: The Application of FragFold Academic Background Protein interactions play a crucial role in cellular life activities, and peptides or protein fragments can regulate protein functions by binding to specific protein interfaces, even acting as inhibitors. Recent developments in high-th...
Impact of Omega-3 Fatty Acids on Lipidomics and Gut Microbiome in Patients with Type 2 Diabetes Background Type 2 Diabetes (T2D) is a common metabolic disorder worldwide, often accompanied by lipid abnormalities such as hypertriglyceridemia (HTG). Lipid abnormalities are significant risk factors for cardiovascular disease (CVD), especially high tri...
GNAO1 (G protein alpha subunit O1) gene mutations are considered one of the primary causes of severe pediatric encephalopathy. This encephalopathy typically manifests as epilepsy, movement disorders, developmental delay, and intellectual disability, with limited effectiveness of current treatments. The GαO protein encoded by the GNAO1 gene is a key...
G-Quadruplexes Catalyze Protein Folding: A Research Report Academic Background Protein folding is a complex and unsolved problem in biology. Many proteins fold very slowly in vitro, far exceeding the time ranges acceptable under physiological conditions. To address this challenge, ATP (adenosine triphosphate)-dependent chaperonins are thought to ac...
Research Report on Identifying New Classes of Financial Price Jumps Using Wavelets Academic Background Price jumps in financial markets refer to significant price fluctuations occurring within an extremely short period, typically caused by exogenous factors (such as sudden news) or endogenous factors (internal market feedback mechanisms). Distingui...
Academic Background In cell biology, focal adhesions (FAs) are key connection points between cells and the extracellular matrix (ECM), linking integrin receptors to the intracellular actin cytoskeleton. They play a crucial role in cell migration and polarization. Talin is a core protein in focal adhesions that directly connects integrin receptors t...
Early Origin of Left-Right Asymmetry in Embryonic Development Academic Background Bilateral symmetry is a widely prevalent body structure feature in the animal kingdom. However, while vertebrates exhibit bilateral symmetry externally, their internal organs display left-right (LR) asymmetry. This asymmetry plays a crucial role during embryonic devel...
Neural Dynamics of Time Perception in the Ventral Premotor Cortex Academic Background Time perception is one of the central questions in neuroscience, particularly how the brain encodes time information as cognitive demands change. Time can be categorized as “long” or “short,” or it can be precisely represented as continuous intervals. The ventral ...
Study of Visual Behavior in Freely Moving Primates: Development and Application of an Innovative Eye-Tracking System Academic Background The visual system is one of the most extensively studied areas within the primate nervous system, particularly concerning the mechanisms of visual pathways in the cerebral cortex. However, current research on how ...
Neuroscientific Research Report on “Domain-General Arousal” Academic Background Arousal is a core concept in neuroscience, referring to fluctuations in brain and body states that underpin motivated behavior. Despite the widespread use of the term “arousal,” its definition has remained ambiguous, with differing interpretations in various textbooks. ...