Behavioral Characterization of Shank3B Mice Across Both Sexes Research Background Autism Spectrum Disorder (ASD) is a group of complex mental disorders characterized by abnormalities in social interaction and repetitive behaviors. The Shank3B mutant ASD mouse model is widely used in research; however, the behavioral phenotype of this model has not ...
Neural Mechanism | Neural Basis of Animal Body Silhouette Classification This article, written by Yue Pu and Shihui Han, published in “neurosci. bull.” in 2024, explores the neural processes of rapid classification and cognition of animal body silhouettes in humans. The study aims to reveal how humans identify and categorize individuals of differen...
Fluoxetine Rescues Excessive Myelin Formation and Psychological Behaviors in a Murine PTSD Model Background Post-traumatic stress disorder (PTSD) is a complex mental disorder characterized by spontaneous intrusions of traumatic memories, avoidance of trauma-related stimuli, negative emotions and cognitions, and hyperarousal. Although existing first...
Study on Serum LDL Promoting Microglial Activation and Exacerbating Demyelination in Neuromyelitis Optica Spectrum Disorder Neuromyelitis Optica Spectrum Disorder (NMOSD) is an autoimmune inflammatory demyelinating disease of the central nervous system (CNS), often accompanied by disruption of the blood-brain barrier (BBB). Dysfunction of lipid met...
Nucleus Accumbens Corticotropin-Releasing Hormone Neurons Project to Bed Nucleus of the Stria Terminalis to Regulate Wakefulness and Positive Emotional States Background The nucleus accumbens (NAc) plays a crucial role in regulating motivation, reward, and many behaviors that depend on high levels of arousal. However, research on the neural mechani...
In the field of neuroscience, epilepsy has always been a disease of great concern, with significant challenges remaining in clinical research and treatment. Among these, the issue of secondary epileptogenesis has had a profound impact on academia and clinical treatment. Secondary epileptogenesis refers to the continuous spread of epileptic activity...
The Role of Occipitotemporal Network in Rapid Reading - An fMRI-based Study Background Reading is the most effective cognitive means for humans to acquire new knowledge. Although most native English-speaking adults read at an average speed of about 200 to 400 words per minute (w/min), many people hope to increase their reading speed to acquire new ...
Revealing Different Cognitive Mechanisms of the Ebbinghaus Illusion Through Neural Oscillations Academic Background Human perception of size in vision is not entirely faithful to the physical world and is highly dependent on context. For example, when an object is surrounded by several smaller objects, it appears larger than when surrounded by larg...
In the latest research paper “Chemokine CCL2 Promotes Excitatory Synaptic Transmission in Hippocampal Neurons via GluA1 Subunit Trafficking” published in “Neurosci. Bull.”, researchers from multiple institutions, including the Shanghai Institute of Neuroscience, Chinese Academy of Sciences, and the School of Life Sciences, Peking University, have d...
Study on Myosin Va-dependent NMDA Receptor Transport Mechanism in Hippocampal Neurons In hippocampal neurons, NMDA receptors (N-Methyl-D-Aspartate Receptor, abbreviated as NMDAR) are a subtype of glutamate receptors, crucial for regulating postsynaptic responses and various brain functions. The number of NMDARs in the postsynaptic region can change...