Biomarkers Associated with the Progression of Infantile Hemangioma: An Exploratory Study Academic Background Infantile Hemangioma (IH) is one of the most common benign tumors in infancy. Although most IH is not apparent at birth, it gradually manifests within the first month of life and undergoes a proliferative phase over approximately one year, f...
Real-World 52-Week Effectiveness Study of Deucravacitinib in Psoriasis Background Introduction Psoriasis is a chronic inflammatory skin disease with a global prevalence of approximately 1% to 3%. This condition not only affects patients’ quality of life (QoL) but is also often accompanied by comorbidities such as cardiovascular diseases, diabetes, ...
History and Prospects of Nagashima-Type Palmoplantar Keratosis Background Palmoplantar keratoderma (PPK) is a group of hereditary or inflammatory skin disorders characterized by hyperkeratosis of the palms and soles, with diverse clinical manifestations and complex diagnostic criteria. Nagashima-type palmoplantar keratosis (NPPK) is the most common...
Stochastic Modeling of Single-Cell Gene Expression Adaptation Reveals Non-Genomic Contribution to Tumor Subclone Evolution Academic Background Cancer is a complex disease whose progression is driven by the evolution of cells that are selected through adaptive advantages for growth. Traditionally, cancer evolution research has focused primarily on g...
New Breakthrough in T Cell Receptor (TCR) Specificity Prediction: The Introduction of the SCEPTR Model Academic Background T cell receptors (TCRs) play a crucial role in the immune system by determining the specificity of immune responses through their binding to peptide-MHC complexes (pMHCs). Understanding the interaction between TCRs and specific...
CDK2 Activity Interference on ERK and p38 KTR Signals and Computational Correction Methods Recently, a paper published in Cell Systems by authors Timothy E. Hoffman, Chengzhe Tian, Varuna Nangia, and others revealed the interference of cyclin-dependent kinase 2 (CDK2) on the kinase translocation reporter (KTR) signals in the extracellular signal-re...
Modular Brain-Machine Interface: Innovative Breakthrough in Neurorecording, Neurostimulation, and Drug Delivery Academic Background Brain-Machine Interfaces (BMIs) are crucial tools in neuroscience and clinical medicine, enabling interactions between the brain and the external world through charge, matter, and information exchange. They are widely ...
Research on an Ultra-Low Power Carbon Dioxide Sensor for Real-Time Breath Monitoring Academic Background Carbon dioxide (CO₂) is a critical gas produced during human respiration, and its real-time monitoring is essential for diagnosing and treating respiratory diseases (e.g., asthma, dyspnea, sleep apnea) as well as metabolic disorders. Traditional...
Minimally Invasive Repair of Bone Implant-Cement Interfaces Using Aerogel Cement and Remote Heating Background Globally, lower limb fractures are the most common type of bone fracture, particularly among the elderly and patients with osteoporosis. In orthopedic surgery, bone cement is widely used to secure implants for the treatment of long bone fr...
Deep Learning-Enhanced Metal-Organic Framework E-Skin for Health Monitoring Academic Background Electronic skin (e-skin) is a technology capable of sensing physiological and environmental stimuli, mimicking human skin functions. In recent years, the potential applications of e-skin in fields such as robotics, sports science, and healthcare monitori...