Endothelin-1 Mediated Brainstem Glial Activation Produces Asthmatic Airway Vagal Hypertonia via Enhanced ATP-P2X4 Receptor Signaling Academic Background Asthma is one of the major non-communicable diseases globally, causing a heavy social and economic burden. Its main clinical symptoms include airflow obstruction, chronic airway inflammation, incre...
JAK1/2 Regulates the Synergistic Effect Between Interferon γ and Lipopolysaccharide in Microglia A research paper titled “JAK1/2 Regulates the Synergistic Effect Between Interferon γ and Lipopolysaccharide in Microglia” was published in the Journal of Neuroimmune Pharmacology in 2024. This article was completed by scholars Alexander P. Young and Ei...
β-Sitosterol Alleviates Neuropathic Pain by Inhibiting the TLR4/NF-κB Signaling Pathway Background Neuropathic pain is a common and difficult-to-treat chronic pain condition in clinical practice, with complex and not fully understood etiology. Research has shown that neuroinflammation is one of the main causes of chronic neuropathic pain. Microglia...
The Role of BMAL1 in LPS-Induced Depressive Behavior and Related “Inflammatory Storm” Introduction According to the 2019 Global Burden of Disease Study, mental disorders are listed as one of the top 10 causes of global burden, with depression being a major contributor. Over 350 million people worldwide suffer from depression, making it the most com...
Protective Effect of Doxycycline-Loaded Calcium Phosphate Nanoparticles on LPS-Induced Neuroinflammation in Mice In the field of neuroscience research, neuroinflammation is an important pathological feature of many neurological diseases. Neuroinflammation is a complex response of the central nervous system (CNS) to various damaging triggers (such a...
Research Overview and Background With the acceleration of global aging, the incidence of ischemic cerebrovascular diseases is also rising significantly. Elderly people over 65 are particularly susceptible to cognitive decline caused by cerebral ischemia, making Chronic Cerebral Hypoperfusion (CCH) a major cause of cognitive impairment and Vascular ...
Low-dose IL-2 treatment rescues cognitive deficits by repairing the imbalance between Treg and Th17 cells at the middle Alzheimer’s disease stage Background Alzheimer’s disease (AD) is an age-related neurodegenerative disorder characterized by neuronal damage, amyloid plaque deposition, and chronic inflammation in the central nervous system (CNS). ...
TPN10475 Inhibits Effector T Lymphocyte Activation and Alleviates Experimental Autoimmune Encephalomyelitis by Promoting TGF-β Signaling Introduction Multiple Sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) mediated by immune cells, with complex etiology and unclear pathogenesis. MS is characterized by ne...
Research Targeting Glucocorticoid Receptor-CCR8 Axis Mediated Bone Marrow T Cell Sequestration to Enhance Anti-tumor T Cell Infiltration in Intracranial Cancer Background Brain tumors, especially glioblastomas (GBMs), show significant resistance to immune checkpoint blockade therapy, partly due to limited T cell infiltration into tumors. GBMs accou...
Background Introduction Sterile neuroinflammation is an important factor driving various neurological diseases. Myelin debris, released during the demyelination process in various neurological diseases (such as stroke, spinal cord injury (SCI), multiple sclerosis (MS), traumatic brain injury (TBI), and neurodegenerative diseases), can act as an inf...