Scientific Report: Study on the Mechanism of Deafness in Cx26-Deficient Mice Introduction Mutations in the Gjb2 gene are the most common cause of autosomal recessive non-syndromic hereditary deafness, accounting for about 50% of all cases. The Cx26 protein encoded by the Gjb2 gene is mainly expressed in cochlear epithelial supporting cells and is r...
Research Background and Objectives Autism Spectrum Disorders (ASDs) are a group of highly heritable neurodevelopmental disorders, primarily characterized by abnormal social interactions, communication deficits, and restricted repetitive behaviors or interests. Previous studies have reported structural changes in brain regions including the hippocam...
Study on YIPF2 Inhibitors Improving Oligodendrocyte Susceptibility to Human Islet Amyloid Polypeptide With the dramatic increase in global diabetes prevalence, the harm of diabetes complications is becoming increasingly prominent. Among them, Diabetic Encephalopathy (DE), as the most common complication in type 2 diabetes, severely affects patients...
Transcutaneous Auricular Vagus Nerve Stimulation Alleviates Preeclampsia-Induced Placental Trophoblast Apoptosis by Inhibiting Mitochondrial Unfolded Protein Response Research Background Preeclampsia is a severe obstetric complication affecting 2%-8% of pregnancies worldwide. This disease not only impacts the health of pregnant women but also serio...
TREM2 Expression on Mouse Astrocytes Prevents Sevoflurane-Induced Developmental Neurotoxicity Through Microglial Pruning of Dendritic Spines in Hippocampal CA1 Region Research Background and Significance Sevoflurane is one of the most widely used anesthetics in pediatric anesthesia. Early multiple exposures to sevoflurane can lead to developmental ...
Mitochondrial Targeting Application of Genetically Encoded Voltage Indicators (GEVIs) Background and Research Motivation Mitochondria, as the energy factories of eukaryotic cells, play crucial roles in various cellular processes, including bioenergetic conversion, metabolite synthesis, cell survival, calcium storage, and heat production. In organs ...
A Novel Autosomal Dominant Parkinsonism/Cerebellar Ataxia Syndrome Caused by Cysteinyl-tRNA Synthetase Mutation Background Recently, a Chinese research team discovered a new pathogenic gene for a rare neurodegenerative disease that presents as a combination of Parkinson’s disease and cerebellar ataxia symptoms, which does not fit the description of...
Research on the Effects of Amorfrutin B on Human Microglia under Hypoxia/Ischemia Conditions: Anti-inflammatory Action, Proliferation Potential, and Mitochondrial State Based on the PPARγ Pathway Research Background Hypoxia/ischemia is a major cause of brain injury in both neonatal and adult populations. Perinatal asphyxia and ischemic stroke are l...
Research Report: β-Hydroxybutyrate Improves Redox State, Cytokine Secretion, and Phagocytic Ability of Glucose-Deprived HMC3 Human Microglia Introduction Microglia are resident neuroimmune cells in the brain, accounting for 5-12% of total neuroglial cells, with strong migration, proliferation, and phagocytic abilities. For example, microglia mainta...
Repeated Low-Dose Lipopolysaccharide Pretreatment Improves Behavioral Abnormalities and Aberrant Immune Responses Induced by Repeated Social Defeat Stress Background Stress significantly impacts human health, with chronic stress particularly inducing various physiological and psychological disorders. The hypothalamic-pituitary-adrenal (HPA) axis is...