The Therapeutic Role of IFN-γ in Experimental Autoimmune Encephalomyelitis is Mediated by Tolerogenic Subsets of Splenic CD11b+ Myeloid Cells Research Background Multiple sclerosis (MS) is a chronic autoimmune disease characterized by demyelination and axonal damage in the central nervous system (CNS). Although the etiology of MS is unclear, both g...

Review of Research on the Treatment Potential for Cognitive Deficits in Traumatic Brain Injury Research Background Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. In Europe, the annual incidence of TBI is at least 4 million cases, imposing a heavy burden on patients, society, and health systems, yet the available ...

Study on the Differential Effects of Blood Flow Restriction Training on Strength Gains and Precise Force Control Research Background Blood Flow Restriction (BFR) training, an emerging method for enhancing muscle strength, has garnered attention from researchers and clinical medicine in recent years. BFR training with low-load resistance exercise en...

Neonatal Respiratory Infections Lead to Brainstem Neuroinflammation Introduction Respiratory infections are one of the most common diseases and causes of morbidity among newborns. During the acute phase, infections are known to cause widespread peripheral inflammation. However, the effect of this inflammation on the critical neural centers that con...

Hippocampal Neurons - The Destructive Force Behind Epilepsy and Mental Disorders Background Introduction Tuberous Sclerosis Complex (TSC) is a complex multi-system genetic disorder that manifests with lesions in the brain, skin, heart, kidneys, and other organs as the patient ages. Clinically, TSC presents with symptoms such as epilepsy and develop...

Background Introduction In this paper, the researchers discuss the impact of aging on the functionality of all cell types in the central nervous system (CNS) and its role in neurological diseases such as multiple sclerosis (MS). However, the molecular mechanisms underlying these age-related changes and their contribution to diseases remain poorly u...

Prediction of Invasiveness and Treatment Resistance Behavior of Pituitary Neuroendocrine Tumors Based on Genome-Wide Loss of Heterozygosity Background: Pituitary neuroendocrine tumors (PitNETs) are mostly benign, but a small portion exhibit invasive and treatment-resistant behaviors, continuing to grow or metastasize even after surgery, conventiona...

Study Report on Abnormal CHCHD2-Related Mitochondrial Pathology in Astrocytes in Kii ALS/PDC I. Research Background Amyotrophic lateral sclerosis/Parkinsonism-dementia complex (ALS/PDC) is a rare and complex neurodegenerative disorder primarily observed in Western Pacific islands such as Japan, Guam, and Papua New Guinea. Patients with this disease...

Research Background Multiple Sclerosis (MS) is a common disease involving lesions in the central nervous system, characterized mainly by demyelination of neuronal axons and neuronal damage. The heterogeneity of the disease is extremely high, meaning that different patients exhibit varying symptoms and pathological mechanisms, which greatly complica...

Co-localization of Gangliosides with Amyloid Beta Plaques in Alzheimer’s Disease Detected by MALDI-MSI and Histology Alzheimer’s Disease (AD) is a progressive neurodegenerative disease characterized by cognitive impairment and behavioral changes. Historically, AD research has focused on misfolded proteins, but with advancements in mass spectrometry...