Research Report: Differential Characteristics and Functions of Regulatory T Cells in the Brain and Spinal Cord Research Background and Motivation This study explored the characteristics and functional differences of regulatory T cells (Tregs) within the central nervous system (CNS). Tregs play a key role in the adaptive immune response, primarily b...

Journal of Neuroinflammation Research Report: Neuroprotective Effects of Prevotella copri Transplantation in a Traumatic Brain Injury Mouse Model Background Traumatic brain injury (TBI) affects over 50 million people globally each year and is considered a significant public health challenge. Secondary injuries associated with TBI are largely relate...

Characterization of Extracellular Vesicles from Spinal Cord Tissue in Experimental Autoimmune Encephalomyelitis Introduction Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system (CNS), and the etiology and methods for predicting disease progression are still under investigation. Experimental autoimmune encephalom...

Through the Regulation of the TRAF5-MAPK Signaling Pathway in Microglial Polarization, CD36 Inhibits and Alleviates White Matter Damage After Traumatic Brain Injury Research Background Traumatic brain injury (TBI) not only damages gray matter but also causes severe white matter damage. White matter damage results in a significant loss of oligodendr...

Nanopolymer Targeting NF-κB and NLRP3 Reduces Neuroinflammation and Enhances Cognitive Function in Aging and Tauopathy Research Background Aging is a major risk factor for cognitive decline and most neurodegenerative diseases, such as Alzheimer’s disease (AD). These cognitive declines are closely related to the pathological aggregation of Tau prote...

The Gender-Dependent Effects of Carbohydrate Sources and Quantity on Caspase-1 Activity in the Central Nervous System of Mice Research Background With the global intensification of aging, the incidence of cognitive impairments and dementia is rapidly increasing, with Alzheimer’s disease being the most common form of senile dementia. Studies have sh...

The Role of Microglia in Neuroinflammation: Metabolic and Gender Differences in Aging Research Background Aging is a major risk factor for neurodegenerative diseases such as Alzheimer’s Disease (AD) and Parkinson’s Disease. Even healthy aging is accompanied by a decline in cognitive function. Previous research has indicated that microglia undergo s...

2-Bromo-1,4-naphthoquinone Promotes CD8+ T Cell Expansion and Limits Th1/Th17 Cell Development to Alleviate Experimental Autoimmune Encephalomyelitis Introduction Multiple Sclerosis (MS) is a chronic autoimmune disease that primarily affects the Central Nervous System (CNS), impacting approximately 3 million people worldwide. The onset of MS is ass...

Key Research on the Role of Macrophages in Peripheral Nerve Regeneration Background and Research Objectives Since the 1990s, research has shown that macrophages play a promoting role in peripheral nerve regeneration, and are particularly important in the conditioning lesion (CL) response. After sciatic nerve injury, macrophages accumulate at the in...

Protective effects of CCR5-overexpressing mesenchymal stem cells on experimental autoimmune uveitis Background Introduction Uveitis is an inflammatory eye disease that seriously threatens vision and can lead to complications such as cataracts, glaucoma, vitreous opacities, retinal detachment, and abnormal retinal vasculature. This disease is widesp...